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XB-ART-44905
Curr Protoc Pharmacol 2005 Jul 01;Chapter 12:Unit12.9. doi: 10.1002/0471141755.ph1209s29.
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Functional screening in the melanophore bioassay.

Jayawickreme C , Sauls H , Watson C , Moncol D , Rimele T , Kenakin T .


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The melanophore bioassay is a robust, sensitive, and versatile procedure for screening G protein-coupled receptors in a variety of formats. Because melanophores contain a wide variety of G proteins, they can be employed as a sensitive, real-time response system for studying transfected receptors and for defining equilibria for drug effects. This assay can be run in 96-well microtiter plates or in open-lawn 1536 format, and can yield conventional agonist-antagonist as well as constitutive assays.

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