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XB-ART-44423
Zhongguo Ying Yong Sheng Li Xue Za Zhi 2001 Nov 01;174:333-6.
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[Modulation of SKF38393 and clonidine on expressed GABA(A) receptors in Xenopus oocytes].

Wang QW , Wang XQ , Wang F , Li ZW .


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The present research is performed on Xenopus oocytes injected with rat DRG mRNA. Modulatory effects of SKF38393 and Clonidine on GABAS(A) receptors expressed in Xenopus oocytes was investigated by two-electrodes voltage-clamp technique, and it is compared with the neurons fresh isolated. It is found that SKF38393 and Clonidine inhibitable GABA(A) receptor function obviously by a concentration-dependent manner. There is an interaction between SKF38393- and Clonidine-induced currents. The inhibition of SKF38393 and Clonidine on GABA(A) receptors is noncompetitive and voltage-independent. The results suggest that the inhibition by SKF38393 and clonidine of GABA-activated current might be a result of phosphorylation of GABA(A) receptor following action of second messenger and the thereby mediated intracellular transduction.

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Species referenced: Xenopus
Genes referenced: drg1