XB-ART-44253
Cold Spring Harb Perspect Biol
2011 Jun 01;36:. doi: 10.1101/cshperspect.a002659.
Show Gene links
Show Anatomy links
Nuclear transfer to eggs and oocytes.
Gurdon JB
,
Wilmut I
.
???displayArticle.abstract???
We review experiments in which somatic cell nuclei are transplanted singly to enucleated eggs (metaphase II) in amphibia and mammals and as multiple nuclei to the germinal vesicle of amphibian oocytes (prophase I). These experiments have shown the totipotency of some somatic cell nuclei, as well as switches in cell type and changes in gene expression. Abnormalities of nuclear transplant embryo development increase greatly as nuclei are taken from progressively more differentiated donor cells. The molecular changes that accompany the reprogramming of transplanted nuclei help to indicate the mechanisms used by eggs and oocytes to reprogram gene expression. We discuss the importance of chromosomal protein exchange, of transcription factor supply, and of chromatin access in reprogramming.
???displayArticle.pubmedLink??? 21555407
???displayArticle.pmcLink??? PMC3098674
???displayArticle.link??? Cold Spring Harb Perspect Biol
???displayArticle.grants??? [+]
Biotechnology and Biological Sciences Research Council , Medical Research Council , Wellcome Trust , G0700711B Medical Research Council
References [+] :
Alberio,
Differential nuclear remodeling of mammalian somatic cells by Xenopus laevis oocyte and egg cytoplasm.
2005, Pubmed,
Xenbase
Alberio, Differential nuclear remodeling of mammalian somatic cells by Xenopus laevis oocyte and egg cytoplasm. 2005, Pubmed , Xenbase
BRIGGS, Nuclear transplantation studies on the early gastrula (Rana pipiens). I. Nuclei of presumptive endoderm. 1960, Pubmed
Barreto, Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. 2007, Pubmed , Xenbase
Beaujean, The effect of interspecific oocytes on demethylation of sperm DNA. 2004, Pubmed
Beaujean, Effect of limited DNA methylation reprogramming in the normal sheep embryo on somatic cell nuclear transfer. 2004, Pubmed
Beyhan, Transcriptional reprogramming of somatic cell nuclei during preimplantation development of cloned bovine embryos. 2007, Pubmed
Bian, Epigenetic marks in somatic chromatin are remodelled to resemble pluripotent nuclei by amphibian oocyte extracts. 2009, Pubmed
Biddle, Xenopus oocytes reactivate muscle gene transcription in transplanted somatic nuclei independently of myogenic factors. 2009, Pubmed , Xenbase
Blelloch, Nuclear cloning of embryonal carcinoma cells. 2004, Pubmed
Boiani, Oct4 distribution and level in mouse clones: consequences for pluripotency. 2002, Pubmed
Bortvin, Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei. 2003, Pubmed
Briggs, Transplantation of Living Nuclei From Blastula Cells into Enucleated Frogs' Eggs. 1952, Pubmed
Bui, The cytoplasm of mouse germinal vesicle stage oocytes can enhance somatic cell nuclear reprogramming. 2008, Pubmed
Byrne, Nuclei of adult mammalian somatic cells are directly reprogrammed to oct-4 stem cell gene expression by amphibian oocytes. 2003, Pubmed , Xenbase
Byrne, Producing primate embryonic stem cells by somatic cell nuclear transfer. 2007, Pubmed
Campbell, Sheep cloned by nuclear transfer from a cultured cell line. 1996, Pubmed
Chen, Embryonic stem cells generated by nuclear transfer of human somatic nuclei into rabbit oocytes. 2003, Pubmed
Collas, Epigenetic reprogramming of nuclei using cell extracts. 2006, Pubmed
Cowan, Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. 2005, Pubmed
DIBERARDINO, TRANSPLANTATION OF NUCLEI FROM THE FROG RENAL ADENOCARCINOMA. II. CHROMOSOMAL AND HISTOLOGIC ANALYSIS OF TUMOR NUCLEAR-TRANSPLANT EMBRYOS. 1965, Pubmed
ELSDALE, A description of the technique for nuclear transplantation in Xenopus laevis. 1960, Pubmed , Xenbase
Eggan, Mice cloned from olfactory sensory neurons. 2004, Pubmed
GURDON, The transplantation of nuclei between two species of Xenopus. 1962, Pubmed , Xenbase
GURDON, The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles. 1962, Pubmed , Xenbase
Gao, Germinal vesicle material is essential for nucleus remodeling after nuclear transfer. 2002, Pubmed
Gonda, Reversible disassembly of somatic nucleoli by the germ cell proteins FRGY2a and FRGY2b. 2003, Pubmed , Xenbase
Gonzalez, Control of DNA replication and its potential clinical exploitation. 2005, Pubmed
Graf, Differentiation plasticity of hematopoietic cells. 2002, Pubmed
Gurdon, The first half-century of nuclear transplantation. 2003, Pubmed
Gurdon, Nuclear reprogramming in cells. 2008, Pubmed
Gurdon, Transcription of muscle-specific actin genes in early Xenopus development: nuclear transplantation and cell dissociation. 1984, Pubmed , Xenbase
Gurdon, From nuclear transfer to nuclear reprogramming: the reversal of cell differentiation. 2006, Pubmed , Xenbase
Gurdon, The developmental capacity of nuclei transplanted from keratinized skin cells of adult frogs. 1975, Pubmed , Xenbase
Gurdon, "Fertile" intestine nuclei. 1966, Pubmed
Gurdon, Injected nuclei in frog oocytes:RNA synthesis and protein exchange. 1976, Pubmed , Xenbase
Hager, Transcription dynamics. 2009, Pubmed
Hammoud, Distinctive chromatin in human sperm packages genes for embryo development. 2009, Pubmed
Hansis, Nuclear reprogramming of human somatic cells by xenopus egg extract requires BRG1. 2004, Pubmed , Xenbase
Hochedlinger, Monoclonal mice generated by nuclear transfer from mature B and T donor cells. 2002, Pubmed
Hochedlinger, Nuclear transplantation: lessons from frogs and mice. 2002, Pubmed
Humpherys, Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei. 2002, Pubmed
Inoue, Generation of cloned mice by direct nuclear transfer from natural killer T cells. 2005, Pubmed
Kennedy, Editorial retraction. 2006, Pubmed
Kikyo, Reprogramming nuclei: insights from cloning, nuclear transfer and heterokaryons. 2000, Pubmed
Kishigami, Significant improvement of mouse cloning technique by treatment with trichostatin A after somatic nuclear transfer. 2006, Pubmed
Koziol, Tpt1 activates transcription of oct4 and nanog in transplanted somatic nuclei. 2007, Pubmed , Xenbase
Lanza, Extension of cell life-span and telomere length in animals cloned from senescent somatic cells. 2000, Pubmed
Lanza, Cloned cattle can be healthy and normal. 2001, Pubmed
Laskey, Genetic content of adult somatic cells tested by nuclear transplantation from cultured cells. 1970, Pubmed
Lemaitre, Mitotic remodeling of the replicon and chromosome structure. 2005, Pubmed , Xenbase
Leno, Hyperphosphorylation of nucleoplasmin facilitates Xenopus sperm decondensation at fertilization. 1996, Pubmed , Xenbase
Li, Odorant receptor gene choice is reset by nuclear transfer from mouse olfactory sensory neurons. 2004, Pubmed
MOORE, Serial back-transfers of nuclei in experiments involving two species of frogs. 1960, Pubmed
McGrath, Inability of mouse blastomere nuclei transferred to enucleated zygotes to support development in vitro. 1984, Pubmed
McKinnell, Transplantation of pluripotential nuclei from triploid frog tumors. 1969, Pubmed
Meissner, Mammalian nuclear transfer. 2006, Pubmed
Miyamoto, Reprogramming events of mammalian somatic cells induced by Xenopus laevis egg extracts. 2007, Pubmed , Xenbase
Miyamoto, Reversible membrane permeabilization of mammalian cells treated with digitonin and its use for inducing nuclear reprogramming by Xenopus egg extracts. 2008, Pubmed , Xenbase
Miyamoto, Cell-free extracts from mammalian oocytes partially induce nuclear reprogramming in somatic cells. 2009, Pubmed
Morgan, Epigenetic reprogramming in mammals. 2005, Pubmed
Munsie, Isolation of pluripotent embryonic stem cells from reprogrammed adult mouse somatic cell nuclei. 2000, Pubmed
Ng, Epigenetic memory of an active gene state depends on histone H3.3 incorporation into chromatin in the absence of transcription. 2008, Pubmed , Xenbase
Niehrs, Active DNA demethylation and DNA repair. 2009, Pubmed
Niwa, Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. 2000, Pubmed
Nolen, X chromosome reactivation and regulation in cloned embryos. 2005, Pubmed
Pereira, Heterokaryon-based reprogramming of human B lymphocytes for pluripotency requires Oct4 but not Sox2. 2008, Pubmed
Prather, Nuclear transplantation in early pig embryos. 1989, Pubmed
SIMNETT, THE DEVELOPMENT OF EMBRYOS DERIVED FROM THE TRANSPLANTATION OF NEURAL ECTODERM CELL NUCLEI IN XENOPUS LAEVIS. 1964, Pubmed , Xenbase
Simonsson, DNA demethylation is necessary for the epigenetic reprogramming of somatic cell nuclei. 2004, Pubmed , Xenbase
Smith, Global gene expression profiles reveal significant nuclear reprogramming by the blastocyst stage after cloning. 2005, Pubmed
Takahashi, Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. 2006, Pubmed
Tamada, Chromatin decondensation and nuclear reprogramming by nucleoplasmin. 2006, Pubmed , Xenbase
Taranger, Induction of dedifferentiation, genomewide transcriptional programming, and epigenetic reprogramming by extracts of carcinoma and embryonic stem cells. 2005, Pubmed
Teranishi, Rapid replacement of somatic linker histones with the oocyte-specific linker histone H1foo in nuclear transfer. 2004, Pubmed , Xenbase
Vassena, Tough beginnings: alterations in the transcriptome of cloned embryos during the first two cell cycles. 2007, Pubmed
Wakayama, Differentiation of embryonic stem cell lines generated from adult somatic cells by nuclear transfer. 2001, Pubmed
Wakayama, Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei. 1998, Pubmed
Wang, Dynamic reprogramming of histone acetylation and methylation in the first cell cycle of cloned mouse embryos. 2007, Pubmed
Weintraub, Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD. 1989, Pubmed
Willadsen, Nuclear transplantation in sheep embryos. , Pubmed
Wilmut, Viable offspring derived from fetal and adult mammalian cells. 1997, Pubmed
Wilmut, Somatic cell nuclear transfer. 2002, Pubmed
Yang, Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning. 2007, Pubmed
Zhou, In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. 2008, Pubmed