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Bioorg Med Chem Lett
2011 Oct 15;2120:6081-4. doi: 10.1016/j.bmcl.2011.08.051.
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Beyond the frog: the evolution of homology models of human IKKβ.
Palermo NY
,
Natarajan A
.
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Nuclear Factor κ B is implicated in tumor progression and chronic inflammatory diseases and is regulated by IκB kinase β (IKKβ). The crystal structure of IKKβ has been recently solved for Xenopus laevis. Homology models of human IKKβ have been developed prior to and after the crystal structure was solved. Here, we compare four models of human IKKβ and evaluate their performance in both broad and focused library docking studies.
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