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F1000 Biol Rep
2009 Mar 17;1:20. doi: 10.3410/B1-20.
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Breaking the A chain: regulating mRNAs in development through CCR4 deadenylase.
Moore J
,
Lasko P
.
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Post-transcriptional mechanisms of gene regulation have long been implicated in specifying embryonic pattern in many organisms. Experiments in Caenorhabditis elegans, Drosophila, and Xenopus have recently converged, pointing to the CCR4 deadenylase complex as a key effector that modulates the expression of proteins from specific germline mRNAs.
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