Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-43353
J Nat Prod 2011 Mar 25;743:483-6. doi: 10.1021/np100746w.
Show Gene links Show Anatomy links

Solid-phase synthesis and biological evaluation of Joro spider toxin-4 from Nephila clavata.

Barslund AF , Poulsen MH , Bach TB , Lucas S , Kristensen AS , Strømgaard K .


???displayArticle.abstract???
Polyamine toxins from orb weaver spiders are attractive pharmacological tools particularly for studies of ionotropic glutamate (iGlu) receptors in the brain. These polyamine toxins are biosynthesized in a combinatorial manner, providing a plethora of related, but structurally complex toxins to be exploited in biological studies. Here, we have used solid-phase synthetic methodology for the efficient synthesis of Joro spider toxin-4 (JSTX-4) (1) from Nephila clavata, providing sufficient amounts of the toxin for biological evaluation at iGlu receptor subtypes using electrophysiology. Biological evaluation revealed that JSTX-4 inhibits iGlu receptors only in high μM concentrations, thereby being substantially less potent than structurally related polyamine toxins.

???displayArticle.pubmedLink??? 21188966
???displayArticle.link??? J Nat Prod