Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Nucleus
2010 Jan 01;15:383-6. doi: 10.4161/nucl.1.5.12332.
Show Gene links
Show Anatomy links
Perspective on the metazoan nuclear pore complex.
Maimon T
,
Medalia O
.
???displayArticle.abstract???
Fusing the inner and outer membranes of the nucleus, the nuclear pore complex (NPC) forms a selective portal which serves as the sole gateway of the nucleus. These aqueous translocation channels allow free diffusion of small molecules and ions, as well as receptor-mediated transport of large macromolecules. Over the last several years major progress has been made in both structural determination of individual nucleopurins (Nups) and their complexes by X-ray crystallography and in structural analysis of the entire assembly by means of cryo-electron tomography. By combining cryo-electron tomography with advanced image processing techniques, the metazoan NPC structure from Xenopus oocytes was resolved to medium resolution, revealing novel details. Here, we discuss new features of the Xenopus NPC and consider future perspectives that will eventually allow resolution of the structure and function of NPCs with high accuracy.
Akey,
Architecture of the Xenopus nuclear pore complex revealed by three-dimensional cryo-electron microscopy.
1993, Pubmed,
Xenbase
Akey,
Architecture of the Xenopus nuclear pore complex revealed by three-dimensional cryo-electron microscopy.
1993,
Pubmed
,
Xenbase
Alber,
The molecular architecture of the nuclear pore complex.
2007,
Pubmed
Beck,
Nuclear pore complex structure and dynamics revealed by cryoelectron tomography.
2004,
Pubmed
Beck,
Snapshots of nuclear pore complexes in action captured by cryo-electron tomography.
2007,
Pubmed
Ben-Harush,
Visualizing cellular processes at the molecular level by cryo-electron tomography.
2010,
Pubmed
Brohawn,
Molecular architecture of the Nup84-Nup145C-Sec13 edge element in the nuclear pore complex lattice.
2009,
Pubmed
Elad,
Structural analysis of the nuclear pore complex by integrated approaches.
2009,
Pubmed
Frenkiel-Krispin,
Structural analysis of a metazoan nuclear pore complex reveals a fused concentric ring architecture.
2010,
Pubmed
,
Xenbase
Förster,
Retrovirus envelope protein complex structure in situ studied by cryo-electron tomography.
2005,
Pubmed
Gerace,
Functional organization of the nuclear envelope.
1988,
Pubmed
Görlich,
Transport between the cell nucleus and the cytoplasm.
1999,
Pubmed
Hetzer,
Border control at the nucleus: biogenesis and organization of the nuclear membrane and pore complexes.
2009,
Pubmed
Kampmann,
Three-dimensional structure and flexibility of a membrane-coating module of the nuclear pore complex.
2009,
Pubmed
Lezon,
Global motions of the nuclear pore complex: insights from elastic network models.
2009,
Pubmed
Lim,
Towards reconciling structure and function in the nuclear pore complex.
2008,
Pubmed
Lucić,
Cryo-electron tomography of cells: connecting structure and function.
2008,
Pubmed
Melcák,
Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding.
2007,
Pubmed
Rabut,
Mapping the dynamic organization of the nuclear pore complex inside single living cells.
2004,
Pubmed
Rout,
The yeast nuclear pore complex: composition, architecture, and transport mechanism.
2000,
Pubmed
Stoffler,
Cryo-electron tomography provides novel insights into nuclear pore architecture: implications for nucleocytoplasmic transport.
2003,
Pubmed
,
Xenbase
Suntharalingam,
Peering through the pore: nuclear pore complex structure, assembly, and function.
2003,
Pubmed
