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J Math Biol
2012 Jan 01;641-2:1-39. doi: 10.1007/s00285-011-0403-y.
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Signal propagation of the MAPK cascade in Xenopus oocytes: role of bistability and ultrasensitivity for a mixed problem.
Blossey R
,
Bodart JF
,
Devys A
,
Goudon T
,
Lafitte P
.
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The MAPK signaling cascade is nowadays understood as a network module highly conserved across species. Its main function is to transfer a signal arriving at the plasma membrane to the cellular interior. Current understanding of 'how' this is achieved involves the notions of ultrasensitivity and bistability which relate to the nonlinear dynamics of the biochemical network, ignoring spatial aspects. Much less, indeed, is so far known about the propagation of the signal through the cytoplasm. In this work we formulate, starting from a Michaelis-Menten model for the MAPK cascade in Xenopus oocytes, a reaction-diffusion model of the cascade. We study this model in one space dimension. Basing ourselves on previous general results on reaction diffusion models, we particularly study for our model the conditions for signal propagation. We show that the existence of a propagating front depends sensitively on the initial and boundary conditions at the plasma membrane. Possible biological consequences of this finding are discussed.
Amiel,
Conserved functions for Mos in eumetazoan oocyte maturation revealed by studies in a cnidarian.
2009, Pubmed,
Xenbase
Amiel,
Conserved functions for Mos in eumetazoan oocyte maturation revealed by studies in a cnidarian.
2009,
Pubmed
,
Xenbase
Angeli,
Detection of multistability, bifurcations, and hysteresis in a large class of biological positive-feedback systems.
2004,
Pubmed
Baert,
Xp42(Mpk1) activation is not required for germinal vesicle breakdown but for Raf complete phosphorylation in insulin-stimulated Xenopus oocytes.
2003,
Pubmed
,
Xenbase
Brown,
Protein scaffolds in MAP kinase signalling.
2009,
Pubmed
Capco,
Analysis of cellular signaling events, the cytoskeleton, and spatial organization of macromolecules during early Xenopus development.
1991,
Pubmed
,
Xenbase
Castro,
c-Mos and cyclin B/cdc2 connections during Xenopus oocyte maturation.
2001,
Pubmed
,
Xenbase
Dupré,
Mos is not required for the initiation of meiotic maturation in Xenopus oocytes.
2002,
Pubmed
,
Xenbase
Ferrell,
The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes.
1998,
Pubmed
,
Xenbase
Ferrell,
Simple, realistic models of complex biological processes: positive feedback and bistability in a cell fate switch and a cell cycle oscillator.
2009,
Pubmed
,
Xenbase
Goldbeter,
An amplified sensitivity arising from covalent modification in biological systems.
1981,
Pubmed
Groisman,
CPEB, maskin, and cyclin B1 mRNA at the mitotic apparatus: implications for local translational control of cell division.
2000,
Pubmed
,
Xenbase
Howard,
The mitogen-activated protein kinase signaling pathway stimulates mos mRNA cytoplasmic polyadenylation during Xenopus oocyte maturation.
1999,
Pubmed
,
Xenbase
Huang,
Ultrasensitivity in the mitogen-activated protein kinase cascade.
1996,
Pubmed
,
Xenbase
Keady,
MAPK interacts with XGef and is required for CPEB activation during meiosis in Xenopus oocytes.
2007,
Pubmed
,
Xenbase
Kholodenko,
Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades.
2000,
Pubmed
Kholodenko,
Signalling ballet in space and time.
2010,
Pubmed
Kholodenko,
Cell-signalling dynamics in time and space.
2006,
Pubmed
Kholodenko,
MAP kinase cascade signaling and endocytic trafficking: a marriage of convenience?
2002,
Pubmed
Markevich,
Long-range signaling by phosphoprotein waves arising from bistability in protein kinase cascades.
2006,
Pubmed
Matten,
Positive feedback between MAP kinase and Mos during Xenopus oocyte maturation.
1996,
Pubmed
,
Xenbase
Muñoz-García,
Positional information generated by spatially distributed signaling cascades.
2009,
Pubmed
Nebreda,
Newly synthesized protein(s) must associate with p34cdc2 to activate MAP kinase and MPF during progesterone-induced maturation of Xenopus oocytes.
1995,
Pubmed
,
Xenbase
Russo,
Kicked by Mos and tuned by MPF-the initiation of the MAPK cascade in Xenopus oocytes.
2009,
Pubmed
,
Xenbase
Santos,
Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate.
2007,
Pubmed
Sheng,
Dissection of c-MOS degron.
2002,
Pubmed
,
Xenbase
Suzuki,
Localization of c-mos mRNA around the animal pole in the zebrafish oocyte with Zor-1/Zorba.
2009,
Pubmed
,
Xenbase
