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Dev Biol
2010 Sep 17;1352:61-9. doi: 10.1016/j.brainres.2010.07.029.
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Subunit-dependent modulation of kainate receptors by muscarinic acetylcholine receptors.
Benveniste M
,
Wilhelm J
,
Dingledine RJ
,
Mott DD
.
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Interactions between cholinergic and glutamatergic neurotransmitter systems influence synaptic transmission and plasticity. While previous studies have examined cross-talk between acetylcholine (ACh) and NMDA or AMPA receptors, little is known about the effect of ACh on kainate receptors (KARs). We show that stimulation of m1 or m3 muscarinic ACh receptors (mAChRs) for 2min potentiates recombinant KAR currents in a long lasting fashion. Muscarinic AChR activation potentiates heteromeric GluK2/GluK4 and GluK2/GluK5 receptors, but not homomeric GluK2 receptors. In hippocampal slices kainate potentiates mossy fiber axon excitability. Transient mAChR activation enhances this action of kainate, suggesting a novel mechanism through which acetylcholine could modulate synaptic transmission in the hippocampus. KAR over-activation has been implicated in excitotoxic cell death. To establish the functional significance of the interaction between mAChRs and KARs we examined the effect of mAChR activation on KAR-mediated excitotoxicity. We find that during pharmacological blockade of NMDA and AMPA receptors, KAR activation with AMPA produces significant cell death in primary cortical culture. Concanavalin A (Con A), which selectively blocks KAR desensitization, markedly increases this KAR-mediated neurotoxicity. Brief activation of mAChRs with pilocarpine significantly enhances KAR-mediated excitotoxicity both in the presence and absence of Con A. We conclude that KARs are modulated in a subunit dependent manner by mAChRs. We suggest that ACh may induce long lasting alterations in neuronal excitability and enhance excitotoxicity in part by potentiating KAR function.
Acquas,
Conditioned and unconditioned stimuli increase frontal cortical and hippocampal acetylcholine release: effects of novelty, habituation, and fear.
1996, Pubmed
Acquas,
Conditioned and unconditioned stimuli increase frontal cortical and hippocampal acetylcholine release: effects of novelty, habituation, and fear.
1996,
Pubmed
Auerbach,
A novel cholinergic induction of long-term potentiation in rat hippocampus.
1994,
Pubmed
Bah,
Maternal transmission disequilibrium of the glutamate receptor GRIK2 in schizophrenia.
2004,
Pubmed
Barberis,
GluR6/KA2 kainate receptors mediate slow-deactivating currents.
2008,
Pubmed
Beguin,
Adrenergic, dopaminergic, and muscarinic receptor stimulation leads to PKA phosphorylation of Na-K-ATPase.
1996,
Pubmed
Blokland,
Acetylcholine: a neurotransmitter for learning and memory?
1995,
Pubmed
Cho,
Regulation of kainate receptors by protein kinase C and metabotropic glutamate receptors.
2003,
Pubmed
Dutar,
The septohippocampal pathway: structure and function of a central cholinergic system.
1995,
Pubmed
Felder,
Muscarinic acetylcholine receptors: signal transduction through multiple effectors.
1995,
Pubmed
Fernández de Sevilla,
Cholinergic-mediated IP3-receptor activation induces long-lasting synaptic enhancement in CA1 pyramidal neurons.
2008,
Pubmed
Gardner,
Convulsant-anticonvulsant interactions on seizure activity and cortical acetylcholine release.
1977,
Pubmed
Giardina,
Excitotoxic profiles of novel, low-affinity kainate receptor agonists in primary cultures of murine cerebellar granule cells.
2001,
Pubmed
Hao,
Calcium/calmodulin-dependent protein kinase II (CaMKII), through NMDA receptors and L-Voltage-gated channels, modulates the serine phosphorylation of GluR6 during cerebral ischemia and early reperfusion period in rat hippocampus.
2005,
Pubmed
Herb,
The KA-2 subunit of excitatory amino acid receptors shows widespread expression in brain and forms ion channels with distantly related subunits.
1992,
Pubmed
Hirbec,
Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP.
2003,
Pubmed
Jensen,
AMPA receptor mediated excitotoxicity in neocortical neurons is developmentally regulated and dependent upon receptor desensitization.
1998,
Pubmed
Jensen,
Role of desensitization and subunit expression for kainate receptor-mediated neurotoxicity in murine neocortical cultures.
1999,
Pubmed
Jope,
Seizures increase acetylcholine and choline concentrations in rat brain regions.
1991,
Pubmed
Kamiya,
Kainate receptor-mediated presynaptic inhibition at the mouse hippocampal mossy fibre synapse.
2000,
Pubmed
Kidd,
Developmental and activity-dependent regulation of kainate receptors at thalamocortical synapses.
1999,
Pubmed
Kirkwood,
Modulation of long-term synaptic depression in visual cortex by acetylcholine and norepinephrine.
1999,
Pubmed
Koh,
Non-NMDA receptor-mediated neurotoxicity in cortical culture.
1990,
Pubmed
Larm,
Neurotoxin domoic acid produces cytotoxicity via kainate- and AMPA-sensitive receptors in cultured cortical neurones.
1997,
Pubmed
Lazzaro,
Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist.
2002,
Pubmed
Lerma,
Roles and rules of kainate receptors in synaptic transmission.
2003,
Pubmed
Marino,
Activation of the genetically defined m1 muscarinic receptor potentiates N-methyl-D-aspartate (NMDA) receptor currents in hippocampal pyramidal cells.
1998,
Pubmed
Markram,
The inositol 1,4,5-trisphosphate pathway mediates cholinergic potentiation of rat hippocampal neuronal responses to NMDA.
1992,
Pubmed
Marrosu,
Microdialysis measurement of cortical and hippocampal acetylcholine release during sleep-wake cycle in freely moving cats.
1995,
Pubmed
Mathern,
Altered hippocampal kainate-receptor mRNA levels in temporal lobe epilepsy patients.
1998,
Pubmed
Mott,
Subunit-dependent modulation of kainate receptors by extracellular protons and polyamines.
2003,
Pubmed
,
Xenbase
Mott,
Phenylethanolamines inhibit NMDA receptors by enhancing proton inhibition.
1998,
Pubmed
,
Xenbase
Mott,
pH-dependent inhibition of kainate receptors by zinc.
2008,
Pubmed
,
Xenbase
Mott,
Subunit-specific desensitization of heteromeric kainate receptors.
2010,
Pubmed
,
Xenbase
Müller,
Specific involvement of Ca(2+)-calmodulin kinase II in cholinergic modulation of neuronal responsiveness.
1992,
Pubmed
O'Neill,
LY377770, a novel iGlu5 kainate receptor antagonist with neuroprotective effects in global and focal cerebral ischaemia.
2000,
Pubmed
Park,
Long-term depression of kainate receptor-mediated synaptic transmission.
2006,
Pubmed
Rebola,
Short-term plasticity of kainate receptor-mediated EPSCs induced by NMDA receptors at hippocampal mossy fiber synapses.
2007,
Pubmed
Schmitz,
Synaptic activation of presynaptic kainate receptors on hippocampal mossy fiber synapses.
2000,
Pubmed
Selak,
A role for SNAP25 in internalization of kainate receptors and synaptic plasticity.
2009,
Pubmed
Swanson,
Effect of RNA editing and subunit co-assembly single-channel properties of recombinant kainate receptors.
1996,
Pubmed
Traynelis,
Control of rat GluR6 glutamate receptor open probability by protein kinase A and calcineurin.
1997,
Pubmed
Vincent,
Kainate receptors in epilepsy and excitotoxicity.
2009,
Pubmed