XB-ART-42649
Bioorg Med Chem Lett
2010 Sep 15;2018:5552-8. doi: 10.1016/j.bmcl.2010.07.043.
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Identification of a novel NR2B-selective NMDA receptor antagonist using a virtual screening approach.
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We report the identification of a novel NR2B-selective NMDAR antagonist with an original scaffold, LSP10-0500. This compound was identified by a virtual high-throughput screening approach on the basis of a quantitative pharmacophore model of NR2B-specific NMDAR antagonists. A SAR study around LSP10-0500 is also described.
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Species referenced: Xenopus
Genes referenced: grin2b