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RNA
2004 Jan 01;101:19-27. doi: 10.1261/rna.5109104.
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The RNA binding domain within the nucleoporin Nup153 associates preferentially with single-stranded RNA.
Ball JR
,
Dimaano C
,
Ullman KS
.
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The nuclear pore protein Nup153 is important for the transport of protein and RNA between the nucleus and cytoplasm. Recently, a novel RNA binding domain (RBD) was mapped within the N-terminal region of Nup153; however, the determinants of RNA association were not characterized. Here we have tested a range of RNAs with different general features to better understand targets recognized by this domain. We have found that the RBD associates with single-stranded RNA with little sequence preference. These results provide new information about a novel RNA binding domain and suggest new models to consider for the contribution of Nup153 to nucleocytoplasmic transport.
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