XB-ART-4175
Cornea
2003 Oct 01;227 Suppl:S2-12.
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Current state of and outlook for organogenesis from undifferentiated cells.
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PURPOSE: The aims of regenerative medicine and artificial internal organ development are, respectively, to regenerate and provide for transplant tissue or organs. METHODS: We summarize recent research on tissue differentiation and organogenesis using stem cells and report our laboratory's research using amphibian undifferentiated cells. RESULTS: We have successfully induced differentiation in cells from Xenopus laevis and generated structures in vitro that function in a similar way to organs when transplanted to Xenopus and newt embryos. We are attempting to establish a system to induce sensory organs, including eyes. CONCLUSION: Our experimental systems in amphibians are useful for organogenetic research, and it is hoped that our techniques can, in the future, be applied to mammals.
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