Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Trace amines depress D(2)-autoreceptor-mediated responses on midbrain dopaminergic cells.
Ledonne A
,
Federici M
,
Giustizieri M
,
Pessia M
,
Imbrici P
,
Millan MJ
,
Bernardi G
,
Mercuri NB
.
???displayArticle.abstract???
BACKGROUND AND PURPOSE: Although trace amines (TAs) are historically considered 'false neurotransmitters' on the basis of their ability to induce catecholamine release, there is evidence that they directly affect neuronal activity via TA receptors, ligand-gated receptor channels and/or sigma receptors. Here, we have investigated the effects of two TAs, tyramine (TYR) and beta-phenylethylamine (beta-PEA), on electrophysiological responses of substantia nigra pars compacta (SNpc) dopaminergic cells to the D(2) receptor agonist, quinpirole.
EXPERIMENTAL APPROACH: Electrophysiological recordings of D(2) receptor-activated G-protein-gated inward rectifier K(+) channel (GIRK) currents were performed on dopaminergic cells from midbrain slices of mice and on Xenopus oocytes expressing D(2) receptors and GIRK channels.
KEY RESULTS: TYR and beta-PEA reversibly reduced D(2) receptor-activated GIRK currents in a concentration-dependent manner on SNpc neurones. The inhibitory effect of TAs was still present in transgenic mice with genetically deleted TA(1) receptors and they could not be reproduced by the selective TA(1) agonist, o-phenyl-3-iodotyramine (O-PIT). Pretreatment with antagonists of sigma1 and sigma2 receptors did not block TA-induced effects. In GTPgammaS-loaded neurones, the irreversibly-activated GIRK-current was still reversibly reduced by beta-PEA. Moreover, beta-PEA did not affect basal or dopamine-evoked GIRK-currents in Xenopus oocytes.
CONCLUSIONS AND IMPLICATIONS: TAs reduced dopamine-induced responses on SNpc neurones by acting at sites different from TA(1), sigma-receptors, D(2) receptors or GIRK channels. Although their precise mechanism of action remains to be identified, TAs, by antagonizing the inhibitory effects of dopamine, may render dopaminergic neurones less sensitive to autoreceptor feedback inhibition and hence enhance their sensitivity to stimulation.
Bailey,
In vivo release of endogenous dopamine, 5-hydroxytryptamine and some of their metabolites from rat caudate nucleus by phenylethylamine.
1987, Pubmed
Bailey,
In vivo release of endogenous dopamine, 5-hydroxytryptamine and some of their metabolites from rat caudate nucleus by phenylethylamine.
1987,
Pubmed
Barroso,
Action of beta-phenylethylamine and related amines on nigrostriatal dopamine neurotransmission.
1996,
Pubmed
Bergman,
Psychomotor stimulant effects of beta-phenylethylamine in monkeys treated with MAO-B inhibitors.
2001,
Pubmed
Berry,
Mammalian central nervous system trace amines. Pharmacologic amphetamines, physiologic neuromodulators.
2004,
Pubmed
Borowsky,
Trace amines: identification of a family of mammalian G protein-coupled receptors.
2001,
Pubmed
Boulton,
Identification, distribution, metabolism, and function of meta and para tyramine, phenylethylamine and tryptamine in brain.
1976,
Pubmed
Boulton,
Trace amines and mental disorders.
1980,
Pubmed
Bradaia,
The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system.
2009,
Pubmed
,
Xenbase
Branchek,
Trace amine receptors as targets for novel therapeutics: legend, myth and fact.
2003,
Pubmed
Bunzow,
Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor.
2001,
Pubmed
Burchett,
The mysterious trace amines: protean neuromodulators of synaptic transmission in mammalian brain.
2006,
Pubmed
Cho,
Receptor-induced depletion of phosphatidylinositol 4,5-bisphosphate inhibits inwardly rectifying K+ channels in a receptor-specific manner.
2005,
Pubmed
Davis,
The trace amines and their acidic metabolites in depression--an overview.
1994,
Pubmed
Durden,
Kinetic measurements of the turnover rates of phenylethylamine and tryptamine in vivo in the rat brain.
1980,
Pubmed
Dyck,
Release of monoamines from striatal slices by phenelzine and beta-phenylethylamine.
1983,
Pubmed
Federici,
Trace amines depress GABA B response in dopaminergic neurons by inhibiting G-betagamma-gated inwardly rectifying potassium channels.
2005,
Pubmed
Fontanilla,
The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator.
2009,
Pubmed
Ford,
The time course of dopamine transmission in the ventral tegmental area.
2009,
Pubmed
Geracitano,
Inhibitory effects of trace amines on rat midbrain dopaminergic neurons.
2004,
Pubmed
Grandy,
Trace amine-associated receptor 1-Family archetype or iconoclast?
2007,
Pubmed
,
Xenbase
Greenshaw,
Depletion of striatal beta-phenylethylamine following dopamine but not 5-HT denervation.
1986,
Pubmed
Guatteo,
Group I metabotropic glutamate receptors mediate an inward current in rat substantia nigra dopamine neurons that is independent from calcium mobilization.
1999,
Pubmed
Hart,
Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues.
2006,
Pubmed
Hauger,
Specific [3H] beta-phenylethylamine binding sites in rat brain.
1982,
Pubmed
Itzhak,
Binding of sigma-ligands to C57BL/6 mouse brain membranes: effects of monoamine oxidase inhibitors and subcellular distribution studies suggest the existence of sigma-receptor subtypes.
1991,
Pubmed
Kabbani,
A proteomic approach to receptor signaling: molecular mechanisms and therapeutic implications derived from discovery of the dopamine D2 receptor signalplex.
2007,
Pubmed
Kitamura,
Beta-phenylethylamine inhibits K+ currents in neocortical neurons of the rat: a possible mechanism of beta-phenylethylamine-induced seizures.
2008,
Pubmed
Kobayashi,
Inhibition of G protein-activated inwardly rectifying K+ channels by ifenprodil.
2006,
Pubmed
,
Xenbase
Kosa,
Effects of beta-phenylethylamine on the hypothalamo-pituitary-adrenal axis in the male rat.
2000,
Pubmed
Lacey,
Dopamine acts on D2 receptors to increase potassium conductance in neurones of the rat substantia nigra zona compacta.
1987,
Pubmed
Lacey,
On the potassium conductance increase activated by GABAB and dopamine D2 receptors in rat substantia nigra neurones.
1988,
Pubmed
Lacey,
Two cell types in rat substantia nigra zona compacta distinguished by membrane properties and the actions of dopamine and opioids.
1989,
Pubmed
Lindemann,
Trace amine-associated receptor 1 modulates dopaminergic activity.
2008,
Pubmed
Lupardus,
Membrane-delimited coupling between sigma receptors and K+ channels in rat neurohypophysial terminals requires neither G-protein nor ATP.
2000,
Pubmed
,
Xenbase
Maguire,
International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature.
2009,
Pubmed
Martin,
The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.
1976,
Pubmed
Mercuri,
Properties of the hyperpolarization-activated cation current Ih in rat midbrain dopaminergic neurons.
1995,
Pubmed
Millan,
Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application.
2006,
Pubmed
Miller,
Primate trace amine receptor 1 modulation by the dopamine transporter.
2005,
Pubmed
Monassier,
sigma(2)-receptor ligand-mediated inhibition of inwardly rectifying K(+) channels in the heart.
2007,
Pubmed
Monnet,
The sigma1 protein as a target for the non-genomic effects of neuro(active)steroids: molecular, physiological, and behavioral aspects.
2006,
Pubmed
NULL,
Guide to Receptors and Channels (GRAC), 4th Edition.
2009,
Pubmed
Nakamura,
Characterization of beta-phenylethylamine-induced monoamine release in rat nucleus accumbens: a microdialysis study.
1998,
Pubmed
Nguyen,
Sigma-binding site ligands inhibit K+ currents in rat locus coeruleus neurons in vitro.
1998,
Pubmed
PERRY,
Urinary excretion of amines in phenylketonuria and mongolism.
1962,
Pubmed
Paterson,
2-Phenylethylamine: a modulator of catecholamine transmission in the mammalian central nervous system?
1990,
Pubmed
Paterson,
The potentiation of cortical neuron responses to noradrenaline by 2-phenylethylamine is independent of endogenous noradrenaline.
1993,
Pubmed
Pessia,
Subunit positional effects revealed by novel heteromeric inwardly rectifying K+ channels.
1996,
Pubmed
,
Xenbase
Philips,
In vivo release of endogenous dopamine from rat caudate nucleus by phenylethylamine.
1983,
Pubmed
Pirri,
A tyramine-gated chloride channel coordinates distinct motor programs of a Caenorhabditis elegans escape response.
2009,
Pubmed
,
Xenbase
Premont,
Following the trace of elusive amines.
2001,
Pubmed
Raiteri,
Effect of sympathomimetic amines on the synaptosomal transport of noradrenaline, dopamine and 5-hydroxytryptamine.
1977,
Pubmed
Ringstad,
Ligand-gated chloride channels are receptors for biogenic amines in C. elegans.
2009,
Pubmed
,
Xenbase
Satoi,
Decreased cerebrospinal fluid levels of beta-phenylethylamine in patients with Rett syndrome.
2000,
Pubmed
Sotnikova,
Trace amine associated receptor 1 and movement control.
2008,
Pubmed
Stoof,
Release and receptor stimulating properties of p-tyramine in rat brain.
1976,
Pubmed
Suppes,
Sensitivity of neuronal dopamine response in the substantia nigra and ventral tegmentum to clozapine, metoclopramide and SCH 23390.
1987,
Pubmed
Vaccari,
High affinity binding of [3H]-tyramine in the central nervous system.
1986,
Pubmed
Werner,
D2, D3, and D4 dopamine receptors couple to G protein-regulated potassium channels in Xenopus oocytes.
1996,
Pubmed
,
Xenbase
Xie,
Trace amine-associated receptor 1 as a monoaminergic modulator in brain.
2009,
Pubmed
Xie,
Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitro.
2007,
Pubmed
Xie,
Modulation of monoamine transporters by common biogenic amines via trace amine-associated receptor 1 and monoamine autoreceptors in human embryonic kidney 293 cells and brain synaptosomes.
2008,
Pubmed
Zhang,
Sigma receptors inhibit high-voltage-activated calcium channels in rat sympathetic and parasympathetic neurons.
2002,
Pubmed
Zhang,
sigma Receptor activation blocks potassium channels and depresses neuroexcitability in rat intracardiac neurons.
2005,
Pubmed
Zhu,
Tyramine excites rat subthalamic neurons in vitro by a dopamine-dependent mechanism.
2007,
Pubmed