Laeknabladid 1995 May 01;815:412-6.

[Oscillatory potentials in the retina: the effects of GABA agonists.].

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We have recorded the electroretinogram from 19 superfused eyecups of the Xeiiopus retina in order to assess the effects of agonists of the inhibitory neurotransmitter gamma-aminobutyric acid (GA notBA), on both oscillatory potentials and the b-wave. We found that in seven eyecups the GABA uptake blocker nipecotic acid (0.1-5 mM) reduced the amplitudes of the oscillatory potentials, without having an effect on the b-wave unless it was applied in larger doses. The GABAB agonist baclofen (0.05-3 mM) reduced the amplitude of the ERG b-wave selectively in seven eyecups tested, without any effect on the amplitude of the oscillatory potentials. The GABAA agonist aminovaleric acid (0.05-3 mM) on the other hand, selectively reduced the oscillatory potentials in five, but had no reliable effects on the Xenopus b-wave. These results suggest that GABAergic mechanisms related to both A and B receptor types induce different influence on the amplitude of the oscillatory potentials and the b-wave.

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Species referenced: Xenopus
Genes referenced: erg gabarap