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Eur Biophys J
2004 May 01;333:265-73. doi: 10.1007/s00249-003-0379-7.
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Role of ligand-gated ion channels in the swimming behaviour of Xenopus tadpoles: experimental data and modelling experiments.
Prime L
,
Pichon Y
.
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The swimming behaviour of lower vertebrates has been used as a model to study the function of simple neuronal circuits. Good examples are the lamprey and the Xenopus tadpole. In these two cases, glutamate-activated NMDA receptors are involved, and the relative importance of the NMDA and non-NMDA receptors as well as the involvement of other ion channels has been studied using a combination of electrophysiological recordings and modelling experiments, but little attention had been paid to their evolution during development. In the present experiments, which have been performed on Xenopus embryos from stages 31 to 42, we have probed the relative importance of the two categories of receptors using selective blockers [respectively dl-2-amino-5-phosphonovaleric acid (APV) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX)]. The sensitivity of the swimming behaviour to APV was found to increase during development and that to CNQX to decrease. Furthermore, it has been observed that the spike activity recorded from the ventral roots is more complex in late embryonic stages that in early embryos. These modifications are associated with changes of the neuronal circuit, some of which correspond to a lengthening of the axon and an increased complexity of the dendritic tree of the motoneurons. We have incorporated these modifications in a simplified model of the central pattern generator built with Neuron software. The results indicate that at least part of the observed changes can be associated with changes in the length of the dendrites and axons.
Buchanan,
Newly identified 'glutamate interneurons' and their role in locomotion in the lamprey spinal cord.
1987, Pubmed
Buchanan,
Newly identified 'glutamate interneurons' and their role in locomotion in the lamprey spinal cord.
1987,
Pubmed
Clarke,
Interneurones in the Xenopus embryo spinal cord: sensory excitation and activity during swimming.
1984,
Pubmed
,
Xenbase
Dale,
Reciprocal inhibitory interneurones in the Xenopus embryo spinal cord.
1985,
Pubmed
,
Xenbase
Dale,
Dual-component amino-acid-mediated synaptic potentials: excitatory drive for swimming in Xenopus embryos.
1985,
Pubmed
,
Xenbase
Dale,
Kinetic characterization of the voltage-gated currents possessed by Xenopus embryo spinal neurons.
1995,
Pubmed
,
Xenbase
Dale,
Excitatory amino acid receptors in Xenopus embryo spinal cord and their role in the activation of swimming.
1984,
Pubmed
,
Xenbase
Dale,
Experimentally derived model for the locomotor pattern generator in the Xenopus embryo.
1995,
Pubmed
,
Xenbase
Fischer,
Adrenoreceptor-mediated modulation of the spinal locomotor pattern during swimming in Xenopus laevis tadpoles.
2001,
Pubmed
,
Xenbase
Gauck,
The contribution of NMDA and AMPA conductances to the control of spiking in neurons of the deep cerebellar nuclei.
2003,
Pubmed
Gleason,
AMPA and NMDA receptors expressed by differentiating Xenopus spinal neurons.
1998,
Pubmed
,
Xenbase
Grillner,
Ion channels and locomotion.
1997,
Pubmed
Grillner,
Neurobiological bases of rhythmic motor acts in vertebrates.
1985,
Pubmed
Grillner,
The motor infrastructure: from ion channels to neuronal networks.
2003,
Pubmed
HODGKIN,
A quantitative description of membrane current and its application to conduction and excitation in nerve.
1952,
Pubmed
Hines,
NEURON: a tool for neuroscientists.
2001,
Pubmed
Kahn,
The central nervous origin of the swimming motor pattern in embryos of Xenopus laevis.
1982,
Pubmed
,
Xenbase
McDearmid,
Aminergic modulation of glycine release in a spinal network controlling swimming in Xenopus laevis.
1997,
Pubmed
,
Xenbase
Perrins,
Cholinergic and electrical synapses between synergistic spinal motoneurones in the Xenopus laevis embryo.
1995,
Pubmed
,
Xenbase
Pichon,
Some aspects of the physiological role of ion channels in the nervous system.
2004,
Pubmed
,
Xenbase
Prime,
N-Methyl-D-aspartate-induced oscillations in whole cell clamped neurons from the isolated spinal cord of Xenopus laevis embryos.
1999,
Pubmed
,
Xenbase
Reith,
Development and role of GABA(A) receptor-mediated synaptic potentials during swimming in postembryonic Xenopus laevis tadpoles.
1999,
Pubmed
,
Xenbase
Roberts,
Intracellular recordings from spinal neurons during 'swimming' in paralysed amphibian embryos.
1982,
Pubmed
,
Xenbase
Roberts,
Mutual Re-excitation with Post-Inhibitory Rebound: A Simulation Study on the Mechanisms for Locomotor Rhythm Generation in the Spinal Cord of Xenopus Embryos.
1990,
Pubmed
,
Xenbase
Roberts,
Properties of networks controlling locomotion and significance of voltage dependency of NMDA channels: stimulation study of rhythm generation sustained by positive feedback.
1995,
Pubmed
,
Xenbase
Roth,
Compartmental models of rat cerebellar Purkinje cells based on simultaneous somatic and dendritic patch-clamp recordings.
2001,
Pubmed
Sands,
A quantitative description of excitatory amino acid neurotransmitter responses on cultured embryonic Xenopus spinal neurons.
1989,
Pubmed
,
Xenbase
Soffe,
Tonic and phasic synaptic input to spinal cord motoneurons during fictive locomotion in frog embryos.
1982,
Pubmed
,
Xenbase
Soffe,
Activity of commissural interneurons in spinal cord of Xenopus embryos.
1984,
Pubmed
,
Xenbase
Soffe,
Activity of myotomal motoneurons during fictive swimming in frog embryos.
1982,
Pubmed
,
Xenbase
Soffe,
Ionic and pharmacological properties of reciprocal inhibition in Xenopus embryo motoneurones.
1987,
Pubmed
,
Xenbase
Sun,
Developmental changes in expression of ion currents accompany maturation of locomotor pattern in frog tadpoles.
1998,
Pubmed
,
Xenbase
Tabak,
Simulation and parameter estimation study of a simple neuronal model of rhythm generation: role of NMDA and non-NMDA receptors.
1998,
Pubmed
,
Xenbase
Wallén,
N-methyl-D-aspartate receptor-induced, inherent oscillatory activity in neurons active during fictive locomotion in the lamprey.
1987,
Pubmed
van Mier,
The development of the dendritic organization of primary and secondary motoneurons in the spinal cord of Xenopus laevis. An HRP study.
1985,
Pubmed
,
Xenbase