Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
J Mol Evol
2004 Jan 01;581:106-14. doi: 10.1007/s00239-003-2529-z.
Show Gene links
Show Anatomy links
Novel neuropeptide Y Y2-like receptor subtype in zebrafish and frogs supports early vertebrate chromosome duplications.
Fredriksson R
,
Larson ET
,
Yan YL
,
Postlethwait JH
,
Larhammar D
.
???displayArticle.abstract???
The Y receptors comprise a family of G-protein coupled receptors with neuropeptide Y-family peptides as endogenous ligands. The Y receptor family has five members in mammals and evolutionary data suggest that it diversified in the two genome duplications proposed to have occurred early in vertebrate evolution. If this theory holds true, it allows for additional family members to be present. We describe here the cloning, pharmacological characterization, tissue distribution, and chromosomal localization of a novel subtype of the Y-receptor family, named Y7, from the zebrafish. We also present Y7 sequences from rainbow trout and two amphibians. The new receptor is most similar to Y2, with 51-54% identity. As Y2 has also been cloned from some of these species, there clearly are two separate Y2-subfamily genes. Chromosomal mapping in zebrafish supports origin of Y7 as a duplicate of Y2 by chromosome duplication in an early vertebrate. Y7 has probably been lost in the lineage leading to mammals. The pharmacological profile of the zebrafish Y7 receptor is different from mammalian Y2, as it does not bind short fragments of NPY with a high affinity. The Y7 receptor supports the theory of early vertebrate genome duplications and suggests that the Y family of receptors is a result of these early genome duplications.
Ammar,
Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene.
1996, Pubmed
Ammar,
Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene.
1996,
Pubmed
Berglund,
Reciprocal mutations of neuropeptide Y receptor Y2 in human and chicken identify amino acids important for antagonist binding.
2002,
Pubmed
Cerdá-Reverter,
Neuropeptide Y family of peptides: structure, anatomical expression, function, and molecular evolution.
2000,
Pubmed
Doods,
BIIE0246: a selective and high affinity neuropeptide Y Y(2) receptor antagonist.
1999,
Pubmed
Dumont,
Neuropeptide Y and neuropeptide Y receptor subtypes in brain and peripheral tissues.
1992,
Pubmed
Gehlert,
[125I]Leu31, Pro34-PYY is a high affinity radioligand for rat PP1/Y4 and Y1 receptors: evidence for heterogeneity in pancreatic polypeptide receptors.
1997,
Pubmed
Goumain,
Identification and distribution of mRNA encoding the Y1, Y2, Y4, and Y5 receptors for peptides of the PP-fold family in the rat intestine and colon.
1998,
Pubmed
Gregor,
Molecular characterization of a second mouse pancreatic polypeptide receptor and its inactivated human homologue.
1996,
Pubmed
Gustafson,
Distribution of the neuropeptide Y Y2 receptor mRNA in rat central nervous system.
1997,
Pubmed
Holland,
Gene duplication: past, present and future.
1999,
Pubmed
Holmberg,
Pharmacological characterization of cloned chicken neuropeptide Y receptors Y1 and Y5.
2002,
Pubmed
Hukriede,
Radiation hybrid mapping of the zebrafish genome.
1999,
Pubmed
Kelly,
Genetic linkage mapping of zebrafish genes and ESTs.
2000,
Pubmed
Kumar,
MEGA2: molecular evolutionary genetics analysis software.
2001,
Pubmed
Larhammar,
Evolution of neuropeptide Y, peptide YY and pancreatic polypeptide.
1996,
Pubmed
Larhammar,
Origins of the many NPY-family receptors in mammals.
2001,
Pubmed
Lundell,
Cloning and characterization of a novel neuropeptide Y receptor subtype in the zebrafish.
1997,
Pubmed
,
Xenbase
Lundin,
Evolution of the vertebrate genome as reflected in paralogous chromosomal regions in man and the house mouse.
1993,
Pubmed
Malmström,
Characterization and molecular cloning of vascular neuropeptide Y receptor subtypes in pig and dog.
1998,
Pubmed
Marklund,
Intron-mediated expression of the human neuropeptide Y Y1 receptor.
2002,
Pubmed
Michel,
XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors.
1998,
Pubmed
Nakamura,
Cloning and functional expression of a cDNA encoding a mouse type 2 neuropeptide Y receptor.
1996,
Pubmed
Narnaware,
Neuropeptide Y stimulates food consumption through multiple receptors in goldfish.
,
Pubmed
Naveilhan,
Complementary and overlapping expression of Y1, Y2 and Y5 receptors in the developing and adult mouse nervous system.
1998,
Pubmed
Postlethwait,
Vertebrate genome evolution and the zebrafish gene map.
1998,
Pubmed
Rose,
Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor.
1995,
Pubmed
Salaneck,
Chicken neuropeptide Y receptor Y2: structural and pharmacological differences to mammalian Y2(1).
2000,
Pubmed
Salaneck,
A neuropeptide Y receptor Y1-subfamily gene from an agnathan, the European river lamprey. A potential ancestral gene.
2001,
Pubmed
Sharma,
Cloning and functional expression of the guinea pig neuropeptide Y Y2 receptor.
1998,
Pubmed
Starbäck,
Neuropeptide Y receptor gene y6: multiple deaths or resurrections?
2000,
Pubmed
Söderberg,
Neuropeptide role of both peptide YY and neuropeptide Y in vertebrates suggested by abundant expression of their mRNAs in a cyclostome brain.
1994,
Pubmed
Taylor,
Comparative genomics provides evidence for an ancient genome duplication event in fish.
2001,
Pubmed
,
Xenbase
Thompson,
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.
1994,
Pubmed
Wagner,
The fate of duplicated genes: loss or new function?
1998,
Pubmed
Wahlestedt,
Neuropeptide Y-related peptides and their receptors--are the receptors potential therapeutic drug targets?
1993,
Pubmed
Woods,
A comparative map of the zebrafish genome.
2000,
Pubmed
Wraith,
Evolution of the neuropeptide Y receptor family: gene and chromosome duplications deduced from the cloning and mapping of the five receptor subtype genes in pig.
2000,
Pubmed