Lee HJ , Wang NX , Shi DL , Zheng JJ .

CA21765 NCI NIH HHS , GM081492 NIGMS NIH HHS , R01 GM081492-03 NIGMS NIH HHS , R01 GM081492-02 NIGMS NIH HHS , R01 GM081492 NIGMS NIH HHS , P30 CA021765 NCI NIH HHS

Babbar, Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer. 2003, Pubmed

Babbar, Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer. 2003, Pubmed
Barker, Mining the Wnt pathway for cancer therapeutics. 2006, Pubmed
Bhattacharyya, Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits. 2006, Pubmed
Boon, Sulindac targets nuclear beta-catenin accumulation and Wnt signalling in adenomas of patients with familial adenomatous polyposis and in human colorectal cancer cell lines. 2004, Pubmed
Brannon, A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus. 1997, Pubmed , Xenbase
Brown, COX-2: a molecular target for colorectal cancer prevention. 2005, Pubmed
Brünger, Crystallography & NMR system: A new software suite for macromolecular structure determination. 1998, Pubmed
Caldwell, Reorganisation of Wnt-response pathways in colorectal tumorigenesis. 2008, Pubmed
Case, The Amber biomolecular simulation programs. 2005, Pubmed
Cheyette, Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation. 2002, Pubmed , Xenbase
Chong, New uses for old drugs. 2007, Pubmed
Dominguez, HADDOCK: a protein-protein docking approach based on biochemical or biophysical information. 2003, Pubmed
Feng, PDZ7 of glutamate receptor interacting protein binds to its target via a novel hydrophobic surface area. 2002, Pubmed
Fujii, An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth. 2007, Pubmed
Gardner, Effect of nonsteroidal anti-inflammatory drugs on beta-catenin protein levels and catenin-related transcription in human colorectal cancer cells. 2004, Pubmed
Grandy, Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled. 2009, Pubmed , Xenbase
Han, Sulindac suppresses beta-catenin expression in human cancer cells. 2008, Pubmed
Iwahara, Improved NMR spectra of a protein-DNA complex through rational mutagenesis and the application of a sensitivity optimized isotope-filtered NOESY experiment. 2001, Pubmed
Jiang, DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications. 2008, Pubmed
Klaus, Wnt signalling and its impact on development and cancer. 2008, Pubmed
Koradi, MOLMOL: a program for display and analysis of macromolecular structures. 1996, Pubmed
Laskowski, AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR. 1996, Pubmed
Lee, Identification of tripeptides recognized by the PDZ domain of Dishevelled. 2009, Pubmed
Lim, Sulindac sulfide and exisulind inhibit expression of the estrogen and progesterone receptors in human breast cancer cells. 2006, Pubmed
Logan, The Wnt signaling pathway in development and disease. 2004, Pubmed
Long, Supramodular structure and synergistic target binding of the N-terminal tandem PDZ domains of PSD-95. 2003, Pubmed
Mizutani, Upregulation and overexpression of DVL1, the human counterpart of the Drosophila dishevelled gene, in prostate cancer. 2005, Pubmed
Moon, WNT and beta-catenin signalling: diseases and therapies. 2004, Pubmed
Okino, Up-regulation and overproduction of DVL-1, the human counterpart of the Drosophila dishevelled gene, in cervical squamous cell carcinoma. 2003, Pubmed
Pan, Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation. 2008, Pubmed , Xenbase
Pellecchia, NMR in drug discovery. 2002, Pubmed
Piazza, Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels. 1997, Pubmed
Polakis, The many ways of Wnt in cancer. 2007, Pubmed
Sato, Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors. 2007, Pubmed
Sauter, Sulindac sulfone modulates beta-catenin in human cholesteatoma cell culture. 2007, Pubmed
Schüttelkopf, PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. 2004, Pubmed
Segditsas, APC and the three-hit hypothesis. 2009, Pubmed
Shan, Optimizing Dvl PDZ domain inhibitor by exploring chemical space. 2009, Pubmed
Shan, Identification of a specific inhibitor of the dishevelled PDZ domain. 2005, Pubmed , Xenbase
Smith, The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cells: evidence of different mechanisms of action. 2000, Pubmed
Suzuki, Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. 2004, Pubmed
Thun, Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues. 2002, Pubmed
Uematsu, Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression. 2003, Pubmed
Uematsu, Wnt pathway activation in mesothelioma: evidence of Dishevelled overexpression and transcriptional activity of beta-catenin. 2003, Pubmed
Ulrich, Non-steroidal anti-inflammatory drugs for cancer prevention: promise, perils and pharmacogenetics. 2006, Pubmed
Umbhauer, The C-terminal cytoplasmic Lys-thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/beta-catenin signalling. 2000, Pubmed , Xenbase
Wallingford, The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity. 2005, Pubmed
Wang, Therapeutic use of PDZ protein-protein interaction antagonism. 2008, Pubmed
Webster, Exisulind in the treatment of prostate cancer. 2005, Pubmed
Wong, Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. 2003, Pubmed , Xenbase
Zhang, Inhibition of Wnt signaling by Dishevelled PDZ peptides. 2009, Pubmed
Zhang, Malignant transformation and antineoplastic actions of nonsteroidal antiinflammatory drugs (NSAIDs) on cyclooxygenase-null embryo fibroblasts. 1999, Pubmed