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The detailed characterization of synaptic plasticity has led to the replacement of simple Hebbian rules by more complex rules depending on the order of presynaptic and postsynaptic action potentials. Here, we describe a mechanism endowing a plasticity rule with additional computational complexity--a dependence on the pattern of presynaptic action potentials. The classical Hebbian rule is based on detection of conjunctive presynaptic and postsynaptic activity by postsynaptic NMDA receptors, but there is also accumulating evidence for the existence of presynaptic NMDA receptors in several brain structures. Here, we examine the role of presynaptic NMDA receptors in defining the temporal structure of the plasticity rule governing induction of long-term depression (LTD) at the cerebellar parallel fiber-Purkinje cell synapse. We show that multiple presynaptic action potentials at frequencies between 40 Hz and 1 kHz are necessary for LTD induction. We characterize the subtype, kinetics, and role of presynaptic NMDA receptors involved in the induction of LTD, showing how the kinetics of the NR2A subunits expressed by parallel fibers implement a high-pass filter plasticity rule that will selectively attenuate synapses undergoing high-frequency bursts of activity. Depending on the type of NMDA receptor subunit expressed, high-pass filters of different corner frequencies could be implemented at other synapses expressing NMDA autoreceptors.
Aiba,
Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice.
1994, Pubmed
Aiba,
Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice.
1994,
Pubmed
Barbour,
Prolonged presence of glutamate during excitatory synaptic transmission to cerebellar Purkinje cells.
1994,
Pubmed
Barbour,
An evaluation of synapse independence.
2001,
Pubmed
Batchelor,
Novel synaptic potentials in cerebellar Purkinje cells: probable mediation by metabotropic glutamate receptors.
1993,
Pubmed
Baude,
The metabotropic glutamate receptor (mGluR1 alpha) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction.
1993,
Pubmed
Berretta,
Tonic facilitation of glutamate release by presynaptic N-methyl-D-aspartate autoreceptors in the entorhinal cortex.
1996,
Pubmed
Binshtok,
NMDA receptors in layer 4 spiny stellate cells of the mouse barrel cortex contain the NR2C subunit.
2006,
Pubmed
Black,
Expression of neuronal nitric oxide synthase corresponds to regions of selective vulnerability to hypoxia-ischaemia in the developing rat brain.
1995,
Pubmed
Casado,
Presynaptic N-methyl-D-aspartate receptors at the parallel fiber-Purkinje cell synapse.
2000,
Pubmed
Casado,
Involvement of presynaptic N-methyl-D-aspartate receptors in cerebellar long-term depression.
2002,
Pubmed
Chadderton,
Integration of quanta in cerebellar granule cells during sensory processing.
2004,
Pubmed
Chen,
Changes in agonist concentration dependence that are a function of duration of exposure suggest N-methyl-D-aspartate receptor nonsaturation during synaptic stimulation.
2001,
Pubmed
Christie,
Dendritic NMDA receptors activate axonal calcium channels.
2008,
Pubmed
Christopherson,
PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain.
1999,
Pubmed
Conquet,
Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1.
1994,
Pubmed
Crepel,
Pairing of pre- and postsynaptic activities in cerebellar Purkinje cells induces long-term changes in synaptic efficacy in vitro.
1991,
Pubmed
Crepel,
Cellular locus of the nitric oxide-synthase involved in cerebellar long-term depression induced by high external potassium concentration.
1994,
Pubmed
Daniel,
Coactivation of metabotropic glutamate receptors and of voltage-gated calcium channels induces long-term depression in cerebellar Purkinje cells in vitro.
1992,
Pubmed
Dickie,
NMDA-induced release of nitric oxide potentiates aspartate overflow from cerebellar slices.
1992,
Pubmed
Duguid,
Retrograde activation of presynaptic NMDA receptors enhances GABA release at cerebellar interneuron-Purkinje cell synapses.
2004,
Pubmed
Duguid,
Novel presynaptic mechanisms for coincidence detection in synaptic plasticity.
2006,
Pubmed
East,
NMDA receptor activation in rat hippocampus induces cyclic GMP formation through the L-arginine-nitric oxide pathway.
1991,
Pubmed
Finch,
Local calcium signalling by inositol-1,4,5-trisphosphate in Purkinje cell dendrites.
,
Pubmed
Fischer,
Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro.
1997,
Pubmed
,
Xenbase
Glitsch,
Presynaptic effects of NMDA in cerebellar Purkinje cells and interneurons.
1999,
Pubmed
Hartell,
Strong activation of parallel fibers produces localized calcium transients and a form of LTD that spreads to distant synapses.
1996,
Pubmed
Humeau,
Presynaptic induction of heterosynaptic associative plasticity in the mammalian brain.
2003,
Pubmed
Häusser,
Dendritic and somatic glutamate receptor channels in rat cerebellar Purkinje cells.
1997,
Pubmed
Hémart,
Receptors and second messengers involved in long-term depression in rat cerebellar slices in vitro: a reappraisal.
1995,
Pubmed
Isope,
Properties of unitary granule cell-->Purkinje cell synapses in adult rat cerebellar slices.
2002,
Pubmed
Ito,
Messengers mediating long-term desensitization in cerebellar Purkinje cells.
1990,
Pubmed
Ito,
Long-lasting depression of parallel fiber-Purkinje cell transmission induced by conjunctive stimulation of parallel fibers and climbing fibers in the cerebellar cortex.
1982,
Pubmed
Jörntell,
Properties of somatosensory synaptic integration in cerebellar granule cells in vivo.
2006,
Pubmed
Kampa,
Kinetics of Mg2+ unblock of NMDA receptors: implications for spike-timing dependent synaptic plasticity.
2004,
Pubmed
Konnerth,
Brief dendritic calcium signals initiate long-lasting synaptic depression in cerebellar Purkinje cells.
1992,
Pubmed
Lev-Ram,
Long-term depression in cerebellar Purkinje neurons results from coincidence of nitric oxide and depolarization-induced Ca2+ transients.
1995,
Pubmed
Lev-Ram,
Synergies and coincidence requirements between NO, cGMP, and Ca2+ in the induction of cerebellar long-term depression.
1997,
Pubmed
Lien,
Visual stimuli-induced LTD of GABAergic synapses mediated by presynaptic NMDA receptors.
2006,
Pubmed
,
Xenbase
Luján,
Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1 alpha, mGluR2 and mGluR5, relative to neurotransmitter release sites.
1997,
Pubmed
Malherbe,
Identification of critical residues in the amino terminal domain of the human NR2B subunit involved in the RO 25-6981 binding pocket.
2003,
Pubmed
,
Xenbase
Marcaggi,
Endocannabinoid signaling depends on the spatial pattern of synapse activation.
2005,
Pubmed
Marcaggi,
Short- and long-term depression of rat cerebellar parallel fibre synaptic transmission mediated by synaptic crosstalk.
2007,
Pubmed
Marvizón,
Neurokinin 1 receptor internalization in spinal cord slices induced by dorsal root stimulation is mediated by NMDA receptors.
1997,
Pubmed
Mayer,
Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones.
,
Pubmed
Miyata,
Local calcium release in dendritic spines required for long-term synaptic depression.
2000,
Pubmed
Monyer,
Developmental and regional expression in the rat brain and functional properties of four NMDA receptors.
1994,
Pubmed
Namiki,
NO signalling decodes frequency of neuronal activity and generates synapse-specific plasticity in mouse cerebellum.
2005,
Pubmed
Nieus,
LTP regulates burst initiation and frequency at mossy fiber-granule cell synapses of rat cerebellum: experimental observations and theoretical predictions.
2006,
Pubmed
Nowak,
Magnesium gates glutamate-activated channels in mouse central neurones.
,
Pubmed
Paoletti,
High-affinity zinc inhibition of NMDA NR1-NR2A receptors.
1997,
Pubmed
,
Xenbase
Piochon,
NMDA receptor contribution to the climbing fiber response in the adult mouse Purkinje cell.
2007,
Pubmed
Renzi,
Climbing-fibre activation of NMDA receptors in Purkinje cells of adult mice.
2007,
Pubmed
Rosenmund,
Expression of NMDA channels on cerebellar Purkinje cells acutely dissociated from newborn rats.
1992,
Pubmed
Sattler,
Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein.
1999,
Pubmed
Shibuki,
Dynamic properties of nitric oxide release from parallel fibres in rat cerebellar slices.
1997,
Pubmed
Shigemoto,
Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells.
1994,
Pubmed
Shin,
An NMDA receptor/nitric oxide cascade is involved in cerebellar LTD but is not localized to the parallel fiber terminal.
2005,
Pubmed
Sjöström,
Neocortical LTD via coincident activation of presynaptic NMDA and cannabinoid receptors.
2003,
Pubmed
Suárez,
Presynaptic NMDA autoreceptors facilitate axon excitability: a new molecular target for the anticonvulsant gabapentin.
2005,
Pubmed
Takechi,
A new class of synaptic response involving calcium release in dendritic spines.
,
Pubmed
Vicini,
Functional and pharmacological differences between recombinant N-methyl-D-aspartate receptors.
1998,
Pubmed
Wang,
Expression of cerebellar long-term depression requires postsynaptic clathrin-mediated endocytosis.
2000,
Pubmed
Woodhall,
NR2B-containing NMDA autoreceptors at synapses on entorhinal cortical neurons.
2001,
Pubmed
Xia,
Cerebellar long-term depression requires PKC-regulated interactions between GluR2/3 and PDZ domain-containing proteins.
2000,
Pubmed
