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An investigation of models of the IP3R channel in Xenopus oocyte.
Shuai JW
,
Yang DP
,
Pearson JE
,
Rüdiger S
.
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We consider different models of inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R) channels in order to fit nuclear membrane patch clamp data of the stationary open probability, mean open time, and mean close time of channels in the Xenopus oocyte. Our results indicate that rather than to treat the tetrameric IP(3)R as four independent and identical subunits, one should assume sequential binding-unbinding processes of Ca(2+) ions and IP(3) messengers. Our simulations also favor the assumption that a channel opens through a conformational transition from a close state to an active state.
Atri,
A single-pool model for intracellular calcium oscillations and waves in the Xenopus laevis oocyte.
1993, Pubmed,
Xenbase
Atri,
A single-pool model for intracellular calcium oscillations and waves in the Xenopus laevis oocyte.
1993,
Pubmed
,
Xenbase
Baran,
Integrated luminal and cytosolic aspects of the calcium release control.
2003,
Pubmed
Berridge,
The versatility and universality of calcium signalling.
2000,
Pubmed
Bezprozvanny,
Bell-shaped calcium-response curves of Ins(1,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum.
1991,
Pubmed
Bezprozvanny,
The inositol 1,4,5-trisphosphate receptors.
2005,
Pubmed
Bruno,
Using independent open-to-closed transitions to simplify aggregated Markov models of ion channel gating kinetics.
2005,
Pubmed
De Young,
A single-pool inositol 1,4,5-trisphosphate-receptor-based model for agonist-stimulated oscillations in Ca2+ concentration.
1992,
Pubmed
Dufour,
Inositol 1,4,5-trisphosphate and calcium regulate the calcium channel function of the hepatic inositol 1,4,5-trisphosphate receptor.
1997,
Pubmed
Foskett,
Inositol trisphosphate receptor Ca2+ release channels.
2007,
Pubmed
Fraiman,
A model of IP3 receptor with a luminal calcium binding site: stochastic simulations and analysis.
2004,
Pubmed
Kaftan,
Inositol 1,4,5-trisphosphate (InsP3) and calcium interact to increase the dynamic range of InsP3 receptor-dependent calcium signaling.
1997,
Pubmed
Lechleiter,
Spiral calcium wave propagation and annihilation in Xenopus laevis oocytes.
1991,
Pubmed
,
Xenbase
Li,
Equations for InsP3 receptor-mediated [Ca2+]i oscillations derived from a detailed kinetic model: a Hodgkin-Huxley like formalism.
1994,
Pubmed
Mak,
Single-channel kinetics, inactivation, and spatial distribution of inositol trisphosphate (IP3) receptors in Xenopus oocyte nucleus.
1997,
Pubmed
,
Xenbase
Mak,
Inositol 1,4,5-trisphosphate [correction of tris-phosphate] activation of inositol trisphosphate [correction of tris-phosphate] receptor Ca2+ channel by ligand tuning of Ca2+ inhibition.
1998,
Pubmed
,
Xenbase
Mak,
Rapid ligand-regulated gating kinetics of single inositol 1,4,5-trisphosphate receptor Ca2+ release channels.
2007,
Pubmed
Mak,
Spontaneous channel activity of the inositol 1,4,5-trisphosphate (InsP3) receptor (InsP3R). Application of allosteric modeling to calcium and InsP3 regulation of InsP3R single-channel gating.
2003,
Pubmed
,
Xenbase
Rüdiger,
Hybrid stochastic and deterministic simulations of calcium blips.
2007,
Pubmed
Shuai,
A kinetic model of single and clustered IP3 receptors in the absence of Ca2+ feedback.
2007,
Pubmed
,
Xenbase
Sneyd,
Models of the inositol trisphosphate receptor.
2005,
Pubmed
Sneyd,
A dynamic model of the type-2 inositol trisphosphate receptor.
2002,
Pubmed
,
Xenbase
Sneyd,
A comparison of three models of the inositol trisphosphate receptor.
2004,
Pubmed
Swillens,
Stochastic simulation of a single inositol 1,4,5-trisphosphate-sensitive Ca2+ channel reveals repetitive openings during 'blip-like' Ca2+ transients.
1998,
Pubmed
,
Xenbase
Yang,
On imposing detailed balance in complex reaction mechanisms.
2006,
Pubmed