XB-ART-3986
Org Lett
2004 Feb 19;64:557-60. doi: 10.1021/ol036341+.
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Biocidal activity of polystyrenes that are cationic by virtue of protonation.
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[structure: see text] Poly(1) kills bacteria (Gram-positive and -negative) and lyses human erythrocytes; this biocidal profile is similar to that of the peptide toxin mellitin. Poly(1) has antibacterial activity comparable to that of a potent derivative of the host defense peptide magainin II, but lacks magainin's selectivity for bacteria over erythrocytes. An analogous N-quaternized polymer, poly(3), is less biocidal than poly(1), suggesting that reversible N-protonation leads to greater biocidal activity than does irreversible N-quaternization.
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Species referenced: Xenopus
Genes referenced: magainins