Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract??? Somatostatin and its receptors have a critical role in mammalian growth through their control pattern of secretion of growth hormone, but the evolutionary history of somatostatin and somatostatin receptors are ill defined. We used comparative whole genome analysis of Danio rerio, Carassius auratus, Xenopus tropicalis, Gallus gallus, Monodelphis domestica, Homo sapiens, Sus scrofa, Bos taurus, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Ovis aries, Equus caballus, Pan troglodytes and Macaca mulatto to identify somatostatin and somatostatin receptors in each species. To date, we have identified a minimum of two genes of somatostatin and five somatostatin receptor genes in mammalian species with variable forms. We established a clear evolutionary history of the somatostatin system and traced the origin of the somatostatin system to 395 million years ago (MYA), identifying critical steps in their evolution.
Baranowska,
Direct effect of cortistatin on GH release from cultured pituitary cells in the rat.
2006, Pubmed
Baranowska,
Direct effect of cortistatin on GH release from cultured pituitary cells in the rat.
2006,
Pubmed
Bargmann,
Neurobiology of the Caenorhabditis elegans genome.
1998,
Pubmed
Brazeau,
Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone.
1973,
Pubmed
Brooke,
The ParaHox gene cluster is an evolutionary sister of the Hox gene cluster.
1998,
Pubmed
Conlon,
Somatostatin- and urotensin II-related peptides: molecular diversity and evolutionary perspectives.
1997,
Pubmed
DeVries,
Defining the origins and evolution of the chemokine/chemokine receptor system.
2006,
Pubmed
Dehal,
The draft genome of Ciona intestinalis: insights into chordate and vertebrate origins.
2002,
Pubmed
Florio,
The somatostatin receptor SSTR1 is coupled to phosphotyrosine phosphatase activity in CHO-K1 cells.
1994,
Pubmed
Fredriksson,
The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints.
2003,
Pubmed
Goodman,
Primate evolution at the DNA level and a classification of hominoids.
1990,
Pubmed
Hervieu,
The localization of somatostatin receptor 1 (sst1) immunoreactivity in the rat brain using an N-terminal specific antibody.
1998,
Pubmed
Hobart,
Cloning and sequence analysis of cDNAs encoding two distinct somatostatin precursors found in the endocrine pancreas of anglerfish.
1980,
Pubmed
Holland,
Gene duplication: past, present and future.
1999,
Pubmed
Jeandel,
Effects of the two somatostatin variants somatostatin-14 and [Pro2, Met13]somatostatin-14 on receptor binding, adenylyl cyclase activity and growth hormone release from the frog pituitary.
1998,
Pubmed
Ji,
The earliest known eutherian mammal.
2002,
Pubmed
Kittilson,
Polygenic expression of somatostatin in rainbow trout, Oncorhynchus mykiss: evidence of a preprosomatostatin encoding somatostatin-14.
1999,
Pubmed
Kong,
Differential expression of messenger RNAs for somatostatin receptor subtypes SSTR1, SSTR2 and SSTR3 in adult rat brain: analysis by RNA blotting and in situ hybridization histochemistry.
1994,
Pubmed
Kumar,
Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis.
1999,
Pubmed
Kumar,
A molecular timescale for vertebrate evolution.
1998,
Pubmed
Kunwar,
Developmental biology: Germ-cell attraction.
2003,
Pubmed
Lin,
Evolution of neuroendocrine peptide systems: gonadotropin-releasing hormone and somatostatin.
1998,
Pubmed
Lin,
Expression of three distinct somatostatin messenger ribonucleic acids (mRNAs) in goldfish brain: characterization of the complementary deoxyribonucleic acids, distribution and seasonal variation of the mRNAs, and action of a somatostatin-14 variant.
1999,
Pubmed
Lundin,
Evolution of the vertebrate genome as reflected in paralogous chromosomal regions in man and the house mouse.
1993,
Pubmed
Moore,
Isolation and characterization of a cDNA encoding for preprosomatostatin containing [Tyr7, Gly10]-somatostatin-14 from the endocrine pancreas of rainbow trout, Oncorhynchus mykiss.
1995,
Pubmed
Moore,
Rainbow trout (Oncorhynchus mykiss) possess two somatostatin mRNAs that are differentially expressed.
1999,
Pubmed
Nishii,
Isolation and characterization of [Pro2]somatostatin-14 and melanotropins from Russian sturgeon, Acipenser gueldenstaedti Brandt.
1995,
Pubmed
Olias,
Regulation and function of somatostatin receptors.
2004,
Pubmed
Patel,
Somatostatin receptors.
1997,
Pubmed
Patel,
Somatostatin and its receptor family.
1999,
Pubmed
Reisine,
Somatostatin.
1995,
Pubmed
Reisine,
Molecular biology of somatostatin receptors.
1995,
Pubmed
Rice,
EMBOSS: the European Molecular Biology Open Software Suite.
2000,
Pubmed
Tostivint,
Occurrence of two somatostatin variants in the frog brain: characterization of the cDNAs, distribution of the mRNAs, and receptor-binding affinities of the peptides.
1996,
Pubmed
Tostivint,
New insight into the molecular evolution of the somatostatin family.
2008,
Pubmed
Trabucchi,
Molecular cloning of the cDNAs and distribution of the mRNAs encoding two somatostatin precursors in the African lungfish Protopterus annectens.
1999,
Pubmed
Trabucchi,
Polygenic expression of somatostatin in the sturgeon Acipenser transmontanus: molecular cloning and distribution of the mRNAs encoding two somatostatin precursors.
2002,
Pubmed
Trede,
The use of zebrafish to understand immunity.
2004,
Pubmed
Vaudry,
Isolation of [Pro2,Met13]somatostatin-14 and somatostatin-14 from the frog brain reveals the existence of a somatostatin gene family in a tetrapod.
1992,
Pubmed
Xing,
Polygenic expression of somatostatin in orange-spotted grouper (Epinephelus coioides): molecular cloning and distribution of the mRNAs encoding three somatostatin precursors.
2005,
Pubmed