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Immunogenetics
2009 Feb 01;612:111-8. doi: 10.1007/s00251-008-0347-6.
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High levels of genetic variation at MHC class II DBB loci in the tammar wallaby (Macropus eugenii).
Cheng Y
,
Siddle HV
,
Beck S
,
Eldridge MD
,
Belov K
.
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High levels of MHC diversity are crucial for immunological fitness of populations, with island populations particularly susceptible to loss of genetic diversity. In this study, the level of MHC class II DBB diversity was examined in tammar wallabies (Macropus eugenii) from Kangaroo Island by genotyping class II-linked microsatellite loci and sequencing of DBB genes. Here we show that the tammar wallaby has at least four expressed MHC class II DBB loci and extensive genetic variation in the peptide-binding region of the DBB genes. These results contradict early studies which suggested that wallabies lacked MHC class II diversity and demonstrate that, in spite of the long-term isolation on an offshore island, this population of wallabies has a high level of DBB diversity.
Aguilar,
High MHC diversity maintained by balancing selection in an otherwise genetically monomorphic mammal.
2004, Pubmed
Aguilar,
High MHC diversity maintained by balancing selection in an otherwise genetically monomorphic mammal.
2004,
Pubmed
Beitz,
TEXshade: shading and labeling of multiple sequence alignments using LATEX2 epsilon.
2000,
Pubmed
Belov,
Marsupial MHC class II beta genes are not orthologous to the eutherian beta gene families.
2004,
Pubmed
Belov,
Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex.
2006,
Pubmed
Bondinas,
The spectrum of HLA-DQ and HLA-DR alleles, 2006: a listing correlating sequence and structure with function.
2007,
Pubmed
Brown,
Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1.
1993,
Pubmed
Browning,
Molecular cloning and characterization of the polymorphic MHC class II DBB from the tammar wallaby (Macropus eugenii).
2004,
Pubmed
Doxiadis,
A highly divergent microsatellite facilitating fast and accurate DRB haplotyping in humans and rhesus macaques.
2007,
Pubmed
Felsenstein,
CONFIDENCE LIMITS ON PHYLOGENIES: AN APPROACH USING THE BOOTSTRAP.
1985,
Pubmed
Holland,
Novel alleles in classical major histocompatibility complex class II loci of the brushtail possum (Trichosurus vulpecula).
2008,
Pubmed
Klein,
MHC, TSP, and the origin of species: from immunogenetics to evolutionary genetics.
2007,
Pubmed
McKenzie,
Low MHC class II variability in a marsupial.
1994,
Pubmed
O'Brien,
The promise of comparative genomics in mammals.
1999,
Pubmed
Pieters,
MHC class II-restricted antigen processing and presentation.
2000,
Pubmed
Saitou,
The neighbor-joining method: a new method for reconstructing phylogenetic trees.
1987,
Pubmed
Santucci,
Selection on MHC-linked microsatellite loci in sheep populations.
2007,
Pubmed
Schneider,
MHC class II genes of a marsupial, the red-necked wallaby (Macropus rufogriseus): identification of new gene families.
1991,
Pubmed
Schneider,
Sequence logos: a new way to display consensus sequences.
1990,
Pubmed
Schwaiger,
Typing of artiodactyl MHC-DRB genes with the help of intronic simple repeated DNA sequences.
1993,
Pubmed
Shiina,
Molecular dynamics of MHC genesis unraveled by sequence analysis of the 1,796,938-bp HLA class I region.
1999,
Pubmed
Siddle,
Characterization of major histocompatibility complex class I and class II genes from the Tasmanian devil (Sarcophilus harrisii).
2007,
Pubmed
Stone,
Identification and sequence analysis of an Mhc class II B gene in a marsupial (Monodelphis domestica).
1999,
Pubmed
Tamura,
MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0.
2007,
Pubmed
Taylor,
High microsatellite diversity and differential structuring among populations of the introduced common brushtail possum, Trichosurus vulpecula, in New Zealand.
2004,
Pubmed
Taylor,
A set of tammar wallaby (Macropus eugenii) microsatellites tested for genetic linkage.
1998,
Pubmed
Thompson,
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.
1994,
Pubmed
Wakefield,
The kangaroo genome. Leaps and bounds in comparative genomics.
2003,
Pubmed
de Groot,
Comparative genetics of a highly divergent DRB microsatellite in different macaque species.
2008,
Pubmed