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XB-ART-3930
Trends Cardiovasc Med 1998 Aug 01;86:264-9. doi: 10.1016/s1050-1738(98)00018-8.
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Cx43 gap junctions in cardiac development.

Lo CW , Wessels A .


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Studies utilizing knockout and transgenic mouse models revealed an important role for connexin 43 (Cx43) gap junctions in cardiac development. This may involve a quantitative requirement for gap junctions in modulating the development of cardiac crest cells. In addition, studies in humans and Xenopus indicate that Cx43 gap junctions also may play a role in regulating heart laterality. Together, these findings indicate that the perturbation of Cx43 function could play a significant role in specific congenital heart malformations.

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Species referenced: Xenopus
Genes referenced: gja1