XB-ART-3930
Trends Cardiovasc Med
1998 Aug 01;86:264-9. doi: 10.1016/s1050-1738(98)00018-8.
Show Gene links
Show Anatomy links
Cx43 gap junctions in cardiac development.
???displayArticle.abstract???
Studies utilizing knockout and transgenic mouse models revealed an important role for connexin 43 (Cx43) gap junctions in cardiac development. This may involve a quantitative requirement for gap junctions in modulating the development of cardiac crest cells. In addition, studies in humans and Xenopus indicate that Cx43 gap junctions also may play a role in regulating heart laterality. Together, these findings indicate that the perturbation of Cx43 function could play a significant role in specific congenital heart malformations.
???displayArticle.pubmedLink??? 14987562
???displayArticle.link??? Trends Cardiovasc Med
Species referenced: Xenopus
Genes referenced: gja1