Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
J Cell Biol
2008 Aug 11;1823:417-9. doi: 10.1083/jcb.200807093.
Show Gene links
Show Anatomy links
Activation of mitotic kinesin by microtubule bundling.
Tomishige M
.
???displayArticle.abstract???
Kinesin-5 family members cross-link and slide parallel microtubules of opposite polarity, an activity that is essential for the formation of a bipolar spindle during mitosis. In this issue, Kapitein et al. (Kapitein, L.C., B.H. Kwok, J.S. Weinger, C.F. Schmidt, T.M. Kapoor, and E.J.G. Peterman. 2008. J. Cell Biol. 182:421-428) demonstrate that microtubule cross-linking triggers the conversion of kinesin-5 motility from a diffusive mode to a directional mode, initiating antiparallel microtubule sliding.
Figure 1. Regulation mechanisms of the processive activities of kinesin subfamily motor proteins. (A) Kinesin-5 on a microtubule switches its motional mode from diffusive to directional upon binding to the second microtubule. (B) Activation mechanisms for the other kinesin subfamilies (see text for detail).
Cai,
Kinesin-1 structural organization and conformational changes revealed by FRET stoichiometry in live cells.
2007, Pubmed
Cai,
Kinesin-1 structural organization and conformational changes revealed by FRET stoichiometry in live cells.
2007,
Pubmed
Dietrich,
The kinesin-1 motor protein is regulated by a direct interaction of its head and tail.
2008,
Pubmed
Helenius,
The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends.
2006,
Pubmed
Kapitein,
Microtubule cross-linking triggers the directional motility of kinesin-5.
2008,
Pubmed
,
Xenbase
Kapitein,
The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks.
2005,
Pubmed
,
Xenbase
Kashina,
A bipolar kinesin.
1996,
Pubmed
Kim,
CENP-E combines a slow, processive motor and a flexible coiled coil to produce an essential motile kinetochore tether.
2008,
Pubmed
,
Xenbase
Klopfenstein,
Role of phosphatidylinositol(4,5)bisphosphate organization in membrane transport by the Unc104 kinesin motor.
2002,
Pubmed
Krzysiak,
Getting in sync with dimeric Eg5. Initiation and regulation of the processive run.
2008,
Pubmed
Kwok,
Allosteric inhibition of kinesin-5 modulates its processive directional motility.
2006,
Pubmed
,
Xenbase
Myers,
Kinesin-5 regulates the growth of the axon by acting as a brake on its microtubule array.
2007,
Pubmed
Nédélec,
Computer simulations reveal motor properties generating stable antiparallel microtubule interactions.
2002,
Pubmed
,
Xenbase
Okada,
Mechanism of the single-headed processivity: diffusional anchoring between the K-loop of kinesin and the C terminus of tubulin.
2000,
Pubmed
Tao,
A homotetrameric kinesin-5, KLP61F, bundles microtubules and antagonizes Ncd in motility assays.
2006,
Pubmed
Tomishige,
Conversion of Unc104/KIF1A kinesin into a processive motor after dimerization.
2002,
Pubmed
Turner,
Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker.
2001,
Pubmed
,
Xenbase
Valentine,
Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro.
2006,
Pubmed
