Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Li R
,
Yue J
,
Zhang Y
,
Zhou L
,
Hao W
,
Yuan J
,
Qiang B
,
Ding JM
,
Peng X
,
Cao JM
.
???displayArticle.abstract??? Nocturnin has been identified as a clock-controlled gene based on its rhythmic expression and night-time peak of transcript level in Xenopus retina. Further studies show that the widespread expression and rhythmicity of nocturnin mRNA level parallel the expression of clock genes. In Xenopus, nocturnin transcription is regulated by cAMP response element-binding protein (CREB) binding the nocturnin element (NE). However, mechanism(s) underlying the regulation of nocturnin transcription in human cells is unknown at present. In this study, we demonstrated that the transcription of human nocturnin gene displayed circadian oscillations in Huh7 cells (a human hepatoma cell line) and was regulated by CLOCK/BMAL1 heterodimer via the E-box of nocturnin promoter. In addition, E-box2 is more efficient than E-box1 in the regulation of CLOCK/BMAL1 on nocturnin transcription in vitro.
Balsalobre,
A serum shock induces circadian gene expression in mammalian tissue culture cells.
1998, Pubmed
Balsalobre,
A serum shock induces circadian gene expression in mammalian tissue culture cells.
1998,
Pubmed
Bunger,
Mop3 is an essential component of the master circadian pacemaker in mammals.
2000,
Pubmed
DeBruyne,
CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock.
2007,
Pubmed
Garbarino-Pico,
Immediate early response of the circadian polyA ribonuclease nocturnin to two extracellular stimuli.
2007,
Pubmed
Gong,
NSPc1 is a cell growth regulator that acts as a transcriptional repressor of p21Waf1/Cip1 via the RARE element.
2006,
Pubmed
Green,
Identification of a novel vertebrate circadian clock-regulated gene encoding the protein nocturnin.
1996,
Pubmed
,
Xenbase
Green,
Loss of Nocturnin, a circadian deadenylase, confers resistance to hepatic steatosis and diet-induced obesity.
2007,
Pubmed
Hirota,
Resetting mechanism of central and peripheral circadian clocks in mammals.
2004,
Pubmed
Hogenesch,
The basic helix-loop-helix-PAS protein MOP9 is a brain-specific heterodimeric partner of circadian and hypoxia factors.
2000,
Pubmed
Honma,
Dec1 and Dec2 are regulators of the mammalian molecular clock.
2002,
Pubmed
Lee,
Posttranslational mechanisms regulate the mammalian circadian clock.
2001,
Pubmed
Liu,
Circadian regulation of nocturnin transcription by phosphorylated CREB in Xenopus retinal photoreceptor cells.
2002,
Pubmed
,
Xenbase
Muñoz,
Circadian Transcription. Thinking outside the E-Box.
2002,
Pubmed
Oishi,
Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genes.
2003,
Pubmed
Reppert,
Coordination of circadian timing in mammals.
2002,
Pubmed
Reppert,
Molecular analysis of mammalian circadian rhythms.
2001,
Pubmed
Wang,
Rhythmic expression of Nocturnin mRNA in multiple tissues of the mouse.
2001,
Pubmed
,
Xenbase
Yamamoto,
Acute physical stress elevates mouse period1 mRNA expression in mouse peripheral tissues via a glucocorticoid-responsive element.
2005,
Pubmed
Yu,
Interactivating feedback loops within the mammalian clock: BMAL1 is negatively autoregulated and upregulated by CRY1, CRY2, and PER2.
2002,
Pubmed
