Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-37868
Neuroreport 2008 Jun 11;199:939-43. doi: 10.1097/WNR.0b013e32830216c7.
Show Gene links Show Anatomy links

RNA editing regulates insect gamma-aminobutyric acid receptor function and insecticide sensitivity.

Es-Salah Z , Lapied B , Le Goff G , Hamon A .


???displayArticle.abstract???
A-to-I pre-mRNA editing by adenosine deaminase enzymes has been reported to enhance protein diversity in the nervous system. In Drosophila, the resistance to dieldrin (RDL) gamma-aminobutyric acid (GABA) receptor subunit displays an editing site (R122) that is close to the putative GABA-binding site. We assessed the functional effects of editing at this site by expressing homomeric RDL receptors in Xenopus oocytes. After replacement of arginine 122 with a glycine, both agonist and fipronil potencies were shifted to the right in either fipronil-sensitive receptors or mutated resistant receptors (A301G/T350M). These data provide the first insight on the influence of RNA editing on GABA receptor function.

???displayArticle.pubmedLink??? 18520997
???displayArticle.link??? Neuroreport