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XB-ART-37641
Cancer Cell 2008 Apr 01;134:293-5. doi: 10.1016/j.ccr.2008.03.011.
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RanBP2: a tumor suppressor with a new twist on TopoII, SUMO, and centromeres.

Navarro MS , Bachant J .


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In vertebrate cells, the small ubiquitin-like modifier SUMO plays a poorly defined role in targeting DNA topoisomerase II (TopoII) to centromeres (CENs) during mitosis, presumably to facilitate the untangling of sister chromatids as cells transition into anaphase. A new study by Dawlaty in the April 4 issue of Cell identifies the nucleoporin RanBP2 as a novel tumor suppressor that acts as a SUMO ligase for TopoII. Analysis of this interaction reveals TopoII recruitment to CENs is likely to play an important role in preventing chromosome segregation errors that lead to cancer.

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Species referenced: Xenopus
Genes referenced: ranbp2 twist1