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Eur J Pharmacol
2007 Nov 14;5731-3:60-4. doi: 10.1016/j.ejphar.2007.07.009.
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Inhibition of human 5-HT(3A) and 5-HT(3AB) receptors by etomidate, propofol and pentobarbital.
Rüsch D
,
Braun HA
,
Wulf H
,
Schuster A
,
Raines DE
.
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The actions of intravenous anaesthetics on 5-HT(3AB) receptors have not been studied. Using oocyte electrophysiology, the effects of etomidate, propofol, and pentobarbital on human 5-HT(3A) and 5-HT(3AB) receptors were studied and compared. Inhibition of peak currents by all three compounds in both receptor subtypes was anaesthetic concentration-dependant and non-competitive. Because the half-maximal inhibitory concentrations for etomidate, propofol and pentobarbital in 5-HT(3A) and 5-HT(3AB) receptors were all above their respective anaesthetic concentrations, the results of our study suggest that neither 5-HT(3) receptor subtype contributes to the anaesthetic actions of etomidate, propofol or pentobarbital.
Appadu,
Interaction of i.v. anaesthetic agents with 5-HT3 receptors.
1996, Pubmed
Appadu,
Interaction of i.v. anaesthetic agents with 5-HT3 receptors.
1996,
Pubmed
Barann,
Recombinant human 5-HT3A receptors in outside-out patches of HEK 293 cells: basic properties and barbiturate effects.
2000,
Pubmed
Barann,
5-HT3 receptors in outside-out patches of N1E-115 neuroblastoma cells: basic properties and effects of pentobarbital.
1997,
Pubmed
Barann,
Inhibition of 5-HT3 receptors by propofol: equilibrium and kinetic measurements.
2000,
Pubmed
Consolo,
Serotonergic facilitation of acetylcholine release in vivo from rat dorsal hippocampus via serotonin 5-HT3 receptors.
1994,
Pubmed
Davies,
The 5-HT3B subunit is a major determinant of serotonin-receptor function.
1999,
Pubmed
,
Xenbase
Funahashi,
Activation of presynaptic 5-HT3 receptors facilitates glutamatergic synaptic inputs to area postrema neurons in rat brain slices.
2004,
Pubmed
Krasowski,
General anaesthetic actions on ligand-gated ion channels.
1999,
Pubmed
Maricq,
Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel.
1991,
Pubmed
,
Xenbase
Monk,
Generation of a selective 5-HT3B subunit-recognising polyclonal antibody; identification of immunoreactive cells in rat hippocampus.
2001,
Pubmed
Morales,
Differential composition of 5-hydroxytryptamine3 receptors synthesized in the rat CNS and peripheral nervous system.
2002,
Pubmed
Niesler,
Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E.
2003,
Pubmed
Patten,
An electrophysiological study of the effects of propofol on native neuronal ligand-gated ion channels.
2001,
Pubmed
Reeves,
Detection of human and rodent 5-HT3B receptor subunits by anti-peptide polyclonal antibodies.
2006,
Pubmed
Solt,
General anesthetic-induced channel gating enhancement of 5-hydroxytryptamine type 3 receptors depends on receptor subunit composition.
2005,
Pubmed
,
Xenbase
Stevens,
Modulation of human 5-hydroxytryptamine type 3AB receptors by volatile anesthetics and n-alcohols.
2005,
Pubmed
,
Xenbase
Sudweeks,
Serotonin 5-HT(3) receptors in rat CA1 hippocampal interneurons: functional and molecular characterization.
2002,
Pubmed
Zhou,
Activation of serotonin receptors modulates synaptic transmission in rat cerebral cortex.
1999,
Pubmed
