Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-36926
Biochem J 2008 Mar 15;4103:535-42. doi: 10.1042/BJ20071453.
Show Gene links Show Anatomy links

Negative regulation of cell-cycle progression by RINGO/Speedy E.

Dinarina A , Ruiz EJ , O'Loghlen A , Mouron S , Perez L , Nebreda AR .


???displayArticle.abstract???
Cell-cycle transitions are controlled by CDKs (cyclin-dependent kinases), whose activation is usually associated with the binding of cyclins. RINGO/Speedy proteins can also bind to and activate CDKs, although they do not have amino acid sequence homology with cyclins. The RINGO/Speedy family members studied so far positively regulate cell-cycle progression. In the present paper, we report the biochemical and functional characterization of RINGO/Speedy E. We show that RINGO/Speedy E is a functionally distant member of this protein family that negatively affects cell-cycle progression. RINGO/Speedy E overexpression inhibits the meiotic progression in Xenopus oocytes as well as the proliferation of mammalian cells. RINGO/Speedy E can bind to endogenous CDK1 and CDK2 in both cellular systems. However, the RINGO/Speedy E-activated CDKs have different substrate specificity than the CDKs activated by other RINGO/Speedy proteins, which may account for their different effects on the cell cycle. Our results indicate that, although all RINGO/Speedy family members can activate CDKs, they may differently regulate cell-cycle progression.

???displayArticle.pubmedLink??? 18072937
???displayArticle.link??? Biochem J


Species referenced: Xenopus
Genes referenced: cdk1 cdk2 spdya