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Glucose Repression of Amylase Gene Expression in DROSOPHILA MELANOGASTER.
Benkel BF
,
Hickey DA
.
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We have previously shown that dietary glucose can reduce amylase activity in both adults and larvae of Drosophila; this reduction in enzyme activity reflects a reduction in the quantity of amylase protein, rather than an inhibition of enzyme activity. Here, we report that we have now defined conditions in which the repressive effect of glucose can be greater than 100-fold. Moreover, this repression is partially counteracted by the addition of exogenous cyclic AMP. We also show that there is a direct correlation between changes in amylase activity and changes in the amount of translatable mRNA as assayed in microinjected Xenopus oocytes. This means that the glucose repression is occurring at a pretranslational stage.
Abraham,
Genetic regulation of tissue-specific expression of amylase structural genes in Drosophila melanogaster.
1978, Pubmed
Abraham,
Genetic regulation of tissue-specific expression of amylase structural genes in Drosophila melanogaster.
1978,
Pubmed
Beier,
Characterization of a regulatory region upstream of the ADR2 locus of S. cerevisiae.
1982,
Pubmed
Doane,
Genetic mechanism for tissue-specific control of alpha-amylase expression in Drosophila melanogaster.
1983,
Pubmed
Federoff,
Carbon catabolite repression of maltase synthesis in Saccharomyces carlsbergensis.
1983,
Pubmed
Geer,
Genetic variation in the dietary sucrose modulation of enzyme activities in Drosophila melanogaster.
1984,
Pubmed
Gurdon,
Use of frog eggs and oocytes for the study of messenger RNA and its translation in living cells.
1971,
Pubmed
,
Xenbase
Haj-Ahmad,
A molecular explanation of frequency-dependent selection in Drosophila.
1982,
Pubmed
Hashimoto,
Transcriptional activation of the rat liver tyrosine aminotransferase gene by cAMP.
1984,
Pubmed
Hickey,
Regulation of amylase activity in Drosophila melanogaster: variation in the number of enzyme molecules produced by different amylase genotypes.
1981,
Pubmed
Hickey,
Regulation of amylase activity in drosophila melanogaster: effects of dietary carbohydrate.
1982,
Pubmed
Levy,
Molecular cloning of alpha-amylase genes from Drosophila melanogaster. II. Clone organization and verification.
1985,
Pubmed
,
Xenbase
Pastan,
Cyclic adenosine 5'-monophosphate in Escherichia coli.
1976,
Pubmed
Reynolds,
HMG CoA reductase: a negatively regulated gene with unusual promoter and 5' untranslated regions.
1984,
Pubmed