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XB-ART-36178
Genetics 1986 Sep 01;1141:137-44. doi: 10.1093/genetics/114.1.137.
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Glucose Repression of Amylase Gene Expression in DROSOPHILA MELANOGASTER.

Benkel BF , Hickey DA .


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We have previously shown that dietary glucose can reduce amylase activity in both adults and larvae of Drosophila; this reduction in enzyme activity reflects a reduction in the quantity of amylase protein, rather than an inhibition of enzyme activity. Here, we report that we have now defined conditions in which the repressive effect of glucose can be greater than 100-fold. Moreover, this repression is partially counteracted by the addition of exogenous cyclic AMP. We also show that there is a direct correlation between changes in amylase activity and changes in the amount of translatable mRNA as assayed in microinjected Xenopus oocytes. This means that the glucose repression is occurring at a pretranslational stage.

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References [+] :
Abraham, Genetic regulation of tissue-specific expression of amylase structural genes in Drosophila melanogaster. 1978, Pubmed