XB-ART-36041
Pharmacol Res
2007 Aug 01;562:148-54. doi: 10.1098/rstb.1982.0002.
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Blockade action of ketanserin and increasing effect of potassium ion on Kv1.3 channels expressed in Xenopus oocytes.
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The goal of this study was to investigate the pharmacological effects of ketanserin (KT) and elevated extracellular potassium ([K+]o) on Kv1.3 potassium channels. Kv1.3 channels were expressed in Xenopus oocytes, and the resulting currents were measured using a two-microelectrode voltage-clamp technique. KT blocked Kv1.3 currents in a concentration-dependent, time-dependent and voltage-independent manner, and accelerated their activation and inactivation. Kv1.3 currents were increased by high [K+]o in a concentration-dependent manner. Our results suggest that KT acts directly on the open state of the Kv1.3 channel, whereas augmentation of extracellular [K] enhances current flow through the channel by increasing the channel's conductance.
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Species referenced: Xenopus laevis
Genes referenced: kcna3