XB-ART-34929
Nat Methods
2007 Jan 01;41:39-42. doi: 10.1038/nmeth975.
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Fast manipulation of cellular cAMP level by light in vivo.
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The flagellate Euglena gracilis contains a photoactivated adenylyl cyclase (PAC), consisting of the flavoproteins PACalpha and PACbeta. Here we report functional expression of PACs in Xenopus laevis oocytes, HEK293 cells and in Drosophila melanogaster, where neuronal expression yields light-induced changes in behavior. The activity of PACs is strongly and reversibly enhanced by blue light, providing a powerful tool for light-induced manipulation of cAMP in animal cells.
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Genes referenced: camp