XB-ART-3487
Biochem Genet
2004 Apr 01;423-4:129-37. doi: 10.1023/b:bigi.0000020468.96238.54.
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Cloning and characterization of a novel human TGF-beta activated kinase-like gene.
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TGF-beta activated kinase (TAK1) plays a critical role in the TGF-beta signaling transduction pathway. By screening a human 18-week fetal brain library, we isolated a novel human TAK1-like (TAKL) gene. The gene encoded a putative protein of 242 amino acids, which shared a homology with human, mouse, and Xenopus TAK1. The TAKL gene was located in chromosome 21q21. Northern blot analysis revealed that the TAKL mRNA was expressed predominantly in peripheral blood leukocytes and ubiquitously in human adult and fetal tissues. TAKL was also expressed strongly in breast carcinoma GI-101, colon adenocarcinoma GI-112, and prostatic adenocarcinoma PC3.
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Species referenced: Xenopus
Genes referenced: btg2 map3k7 map3k7cl tgfb1