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Biochem J
2004 Aug 15;382Pt 1:231-7. doi: 10.1042/BJ20040555.
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Identification of a novel receptor for an invertebrate oxytocin/vasopressin superfamily peptide: molecular and functional evolution of the oxytocin/vasopressin superfamily.
Kawada T
,
Kanda A
,
Minakata H
,
Matsushima O
,
Satake H
.
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Annetocin is structurally related to an OT (oxytocin)/VP (vasopressin) family peptide, which has been isolated from the earthworm Eisenia foetida and has been shown to induce OT-like egg-laying behaviour. We now report the identification of an endogenous AnR (annetocin receptor). The deduced AnR precursor displays high sequence similarity with OT/VP receptors. Genomic analysis of the AnR gene revealed that the intron-inserted position is conserved between the AnR gene and the mammalian OT/VP receptor genes. These results indicate that AnR and mammalian OT/VP receptors share a common ancestor gene. Administration of annetocin to the AnR expressed in Xenopus oocytes induced a calcium-dependent signal transduction. Reverse transcriptase-PCR analysis and in situ hybridization showed that the AnR gene is expressed specifically in the nephridia located in the clitellum region, although the nephridia are distributed throughout the worm body. This result suggests that annetocin induces egg-laying behaviour through its action on the nephridia. This is the first description concerning the functional correlation between an invertebrate OT/VP-related peptide and egg-laying behaviour.
Acher,
Neurohypophysial peptide systems: processing machinery, hydroosmotic regulation, adaptation and evolution.
1993,
Pubmed
Acher,
Molecular evolution of fish neurohypophysial hormones: neutral and selective evolutionary mechanisms.
1996,
Pubmed
Adan,
Comparison of the estrogen responsiveness of the rat and bovine oxytocin gene promoters.
1991,
Pubmed
Adan,
Thyroid hormone regulates the oxytocin gene.
1992,
Pubmed
Adan,
A composite hormone response element mediates the transactivation of the rat oxytocin gene by different classes of nuclear hormone receptors.
1993,
Pubmed
Bockaert,
Molecular tinkering of G protein-coupled receptors: an evolutionary success.
1999,
Pubmed
Burbach,
Repression of estrogen-dependent stimulation of the oxytocin gene by chicken ovalbumin upstream promoter transcription factor I.
1994,
Pubmed
Cruz,
Invertebrate vasopressin/oxytocin homologs. Characterization of peptides from Conus geographus and Conus straitus venoms.
1987,
Pubmed
Hoyle,
Neuropeptide families and their receptors: evolutionary perspectives.
1999,
Pubmed
Hoyle,
Neuropeptide families: evolutionary perspectives.
1998,
Pubmed
Inoue,
Structural organization of the human oxytocin receptor gene.
1994,
Pubmed
Kanda,
Cloning of Octopus cephalotocin receptor, a member of the oxytocin/vasopressin superfamily.
2003,
Pubmed
,
Xenbase
Kimura,
Structure and expression of a human oxytocin receptor.
1992,
Pubmed
,
Xenbase
Lolait,
Cloning and characterization of a vasopressin V2 receptor and possible link to nephrogenic diabetes insipidus.
1992,
Pubmed
Mohr,
Sequence analysis of the promoter region of the rat vasopressin gene.
1990,
Pubmed
Mohr,
Functional characterization of estrogen and glucocorticoid responsive elements in the rat oxytocin gene.
1991,
Pubmed
Murasawa,
Structure of the rat V1a vasopressin receptor gene and characterization of its promoter region and complete cDNA sequence of the 3'-end.
1995,
Pubmed
Nathanson,
Mechanisms of subcellular cytosolic Ca2+ signaling evoked by stimulation of the vasopressin V1a receptor.
1992,
Pubmed
,
Xenbase
Oumi,
Annetocin, an annelid oxytocin-related peptide, induces egg-laying behavior in the earthworm, Eisenia foetida.
1996,
Pubmed
Oumi,
Annetocin: an oxytocin-related peptide isolated from the earthworm, Eisenia foetida.
1994,
Pubmed
Pardy,
The identification of a cis-acting element involved in cyclic 3',5'-adenosine monophosphate regulation of bovine vasopressin gene expression.
1992,
Pubmed
Proux,
Identification of an arginine vasopressin-like diuretic hormone from Locusta migratoria.
1987,
Pubmed
Reich,
A new peptide of the oxytocin/vasopressin family isolated from nerves of the cephalopod Octopus vulgaris.
1992,
Pubmed
Richard,
The human oxytocin gene promoter is regulated by estrogens.
1990,
Pubmed
Salzet,
Isolation, structural characterization and biological function of a lysine-conopressin in the central nervous system of the pharyngobdellid leech Erpobdella octoculata.
1993,
Pubmed
Satake,
Evidence for conservation of the vasopressin/oxytocin superfamily in Annelida.
1999,
Pubmed
Sugimoto,
Molecular cloning and functional expression of a cDNA encoding the human V1b vasopressin receptor.
1994,
Pubmed
,
Xenbase
Takahama,
Immunohistochemical Localization of Annetocin, an Earthworm Oxytocin-Related Peptide, and Identification and Ultrastructural Characteristics of the Annetocin-Secretory Cells in the Oligochaete Earthworm Eisenia foetida.
1998,
Pubmed
Takuwa-Kuroda,
Octopus, which owns the most advanced brain in invertebrates, has two members of vasopressin/oxytocin superfamily as in vertebrates.
2003,
Pubmed
Thibonnier,
Structure, sequence, expression, and chromosomal localization of the human V1a vasopressin receptor gene.
1996,
Pubmed
Thibonnier,
Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor.
1994,
Pubmed
Verbeeck,
Regulation of vasopressin messenger RNA levels in the small cell lung carcinoma cell line GLC-8: interactions between glucocorticoids and second messengers.
1991,
Pubmed
Wehrenberg,
The COUP transcription factor (COUP-TF) is directly involved in the regulation of oxytocin gene expression in luteinizing bovine granulosa cells.
1992,
Pubmed
van Kesteren,
Co-evolution of ligand-receptor pairs in the vasopressin/oxytocin superfamily of bioactive peptides.
1996,
Pubmed
,
Xenbase
van Kesteren,
A novel G protein-coupled receptor mediating both vasopressin- and oxytocin-like functions of Lys-conopressin in Lymnaea stagnalis.
1995,
Pubmed
,
Xenbase
van Kesteren,
Evolution of the vasopressin/oxytocin superfamily: characterization of a cDNA encoding a vasopressin-related precursor, preproconopressin, from the mollusc Lymnaea stagnalis.
1992,
Pubmed
