XB-ART-32457
C R Acad Hebd Seances Acad Sci D
1976 Jul 19;2833:259-62.
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[Influence of actinomycin D on Xenopus heart differentiation in organ culture].
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The cardiac differentiation of the African clawed Toad was studied in culture with Actinomycin D. In terms of drug amounts used and the duration of treatment, a limit coefficient was defined, beyond which the heart did not again differentiate. The results were interpreted by the existence of a threshold in the inhibition of ARNr synthesis, whose total turn-over seemed to be 24 hours.
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