Acta Physiol Scand 1977 Mar 01;993:361-7.

Slow action of Ca on myelinated nerve fibres of Xenopus laevis.

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Single myelinated nerve fibres were isolated and the nodal currents were recorded with potential clamp technique. Rapid solution changes were performed by use of a recording chamber so shaped that it had a minimal dead space. A volume ten times larger than the dead space flowed past the node within about 20 ms. The half-time of the change in Na current (INa)amplitude associated with changes between solutions of different [Na]:s was 100-150 ms, whereas the half-time of the change in INa associated with changes between solutions of different [Ca]:s was 200-300 ms. The external [Ca] affects INa through its action on the Na permeability properties of the nodal membrane. The difference in rate of effect between changes in [Na] and [Ca] was also noticeable when simultaneous changes were performed. These findings are discussed with regard to the properties of the nodal gap.

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Species referenced: Xenopus laevis
Genes referenced: nodal nodal1