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J Virol
1978 Nov 01;282:665-70. doi: 10.1128/JVI.28.2.665-670.1978.
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Translation of type C viral RNAs in Xenopus laevis oocytes: evidence that the 120,000-molecular-weight polyprotein expressed in Abelson leukemia virus-transformed cells is virus coded.
Reynolds RK
,
van de Ven WJ
,
Stephenson JR
.
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The genomic RNA of Abelson leukemia virus (AbLV) has been purified and translated in Xenopus laevis oocytes. The primary AbLV-specific protein synthesized is a polyprotein corresponding in molecular weight and immunological properties to a previously described p15 and p12 containing 110,000- to 130,000-molecular-weight polyprotein expressed in AbLV-transformed cells. In contrast, translation of woolly monkey sarcoma virus genomic RNA resulted in symthesis of a 55,000-molecular-weight polyprotein consisting of woolly helper virus p30, p15, and p12. These findings demonstrate the value of the X. laevis oocyte in vitro system for studies of translational products of replication-defective transforming viruses and establish the virus-coded nature of the nonstructural component of the 110,000- to 130,000-molecular-weight polyprotein expressed in AbLV-transformed cells.
Aaronson,
Endogenous type-C RNA viruses of mammalian cells.
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Aaronson,
Endogenous type-C RNA viruses of mammalian cells.
1976,
Pubmed
Barbacid,
gag Gene of mammalian type-C RNA tumour viruses.
1976,
Pubmed
Bonner,
A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels.
1974,
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Gurdon,
Use of frog eggs and oocytes for the study of messenger RNA and its translation in living cells.
1971,
Pubmed
,
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Hartley,
Naturally occurring murine leukemia viruses in wild mice: characterization of a new "amphotropic" class.
1976,
Pubmed
Khan,
Feline leukemia virus: biochemical and immunological characterization of gag gene-coded structural proteins.
1977,
Pubmed
Laemmli,
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
1970,
Pubmed
Mellon,
Subgenomic, cellular Rous sarcoma virus RNAs contain oligonucleotides from the 3' half and the 5' terminus of virion RNA.
1977,
Pubmed
Reynolds,
Cells nonproductively transformed by Abelson murine leukemia virus express a high molecular weight polyprotein containing structural and nonstructural components.
1978,
Pubmed
Reynolds,
Intracistronic mapping of the murine type C viral gag gene by use of conditional lethal replication mutants.
1977,
Pubmed
Rothenberg,
Analysis of a 5' leader sequence on murine leukemia virus 21S RNA: heteroduplex mapping with long reverse transcriptase products.
1978,
Pubmed
Sacks,
Murine leukemia virus (T-8)-transformed cells: identification of a precursor polyprotein containing gag gene-coded proteins (p15 and p12) and a nonstructural component.
1978,
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Salden,
Translation of oncogenic virus RNA in Xenopus laevis oocytes.
1976,
Pubmed
,
Xenbase
Scher,
Direct transformation of 3T3 cells by Abelson murine leukaemia virus.
1975,
Pubmed
Scolnick,
Purification and characterisation of viral RNA of a sarcoma virus isolated from a woolly monkey.
,
Pubmed
Scolnick,
Studies on the nucleic acid sequences of Kirsten sarcoma virus: a model for formation of a mammalian RNA-containing sarcoma virus.
1973,
Pubmed
Sherr,
Pseudotypes of feline sarcoma virus contain an 85,000-dalton protein with feline oncornavirus-associated cell membrane antigen (FOCMA) activity.
1978,
Pubmed
Stephenson,
Feline oncornavirus-associated cell membrane antigen: evidence for an immunologically crossreactive feline sarcoma virus-coded protein.
1977,
Pubmed
Stephenson,
Biochemical and immunological properties of gag genecoded structural proteins of endogenous tyep C RNA tumor viruses of diverse mammalian species.
1977,
Pubmed
Tsuchida,
Size of virus-specific RNA in B-34, a hamster tumor cell producing nucleic acids of type C viruses from three species.
1975,
Pubmed
Witte,
Identification of an Abelson murine leukemia virus-encoded protein present in transformed fibroblast and lymphoid cells.
1978,
Pubmed
