Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Internal histoincompatability during amphibian metamorphosis?
Jones SE
,
Ruben LN
.
???displayArticle.abstract???
Larval amphibia are immunologically competent. Yet during metamorphosis, various regressive and progressive processes replace larval with adult structures. These new structures are thought to arise in an immunological environment which provides protection from rejection of non-larval targets. Pre-metamorphic larvae and post-metamorphic adults require carrier-primed amplification in order to generate an anti-hapten response. However, we find that the response to a single challenge of the hapten, TNP, conjugated to a thymus-dependent (TD) carrier, sheep erythrocytes, is substantial in the absence of carrier priming early in metamorphosis. In contrast, the response to TNP on LPS, a thymus-independent carrier, is unaffected by metamorphosis, We suggest that a unique internal histoincompatibility between larval and adult lymphoid cells may provide a substitute for the carrier-priming requirement in the hapten-TD carrier response during metamorphosis.
Bernardini,
[Development after metamorphosis of immunologic competence between cutaneous homografts in Xenopus leavis Daudin].
1969, Pubmed,
Xenbase
Bernardini,
[Development after metamorphosis of immunologic competence between cutaneous homografts in Xenopus leavis Daudin].
1969,
Pubmed
,
Xenbase
Bovbjerg,
Rejection of skin homografts in larvae of Rana pipiens.
1966,
Pubmed
Chardonnens,
Induction of skin allograft tolerance during metamorphosis of the toad Xenopus laevis: a possible model for studying generation of self tolerance to histocompatibility antigens.
1973,
Pubmed
,
Xenbase
Chardonnens,
Tissue typing by skin grafting during metamorphosis of the toad Xenopus laevis (Daudin).
1975,
Pubmed
,
Xenbase
Du Pasquier,
Ontogeny of immunity in amphibians: changes in antibody repertoires and appearance of adult major histocompatibility antigens in Xenopus.
1979,
Pubmed
,
Xenbase
Edwards,
Surface characteristics of spleen cell-erythrocyte rosette formation in the grass frog Rana pipiens.
1975,
Pubmed
Eshhar,
Activation of T and B lymphocytes in vitro. V. Cellular locus, metabolism and genetics of induction, and production of the allogeneic effect factor.
1977,
Pubmed
Gershon,
T cell control of antibody production.
1974,
Pubmed
Gruenewald,
The effect of adult thymectomy upon helper function in Xenopus laevis, the South African clawed toad.
1979,
Pubmed
,
Xenbase
Horton,
Use of different carriers to demonstrate thymic-dependent and thymic-independent anti-trinitrophenyl reactivity in the ambhibian Xenopus laevis.
1979,
Pubmed
,
Xenbase
Hunter,
Mode of action of a supernatant activity from T-cell cultures that nonspecifically stimulates the humoral immune response.
1974,
Pubmed
Jurd,
Surface immunoglobulins on Xenopus laevis lymphocytes.
1976,
Pubmed
,
Xenbase
Klaus,
The immunological properties of haptens coupled to thymus-independent carrier molecules. II. The influence of the graft-versus-host reaction on primary antibody responses to hapten-coupled polysaccharides and proteins.
1974,
Pubmed
Manning,
Thymic function in amphibians.
1975,
Pubmed
,
Xenbase
Raff,
Role of thymus-derived lymphocytes in the secondary humoral immune response in mice.
1970,
Pubmed
Rittenberg,
Immunogenicity of trinitrophenyl-hemocyanin: production of primary and secondary anti-hapten precipitins.
1966,
Pubmed
Rittenberg,
Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen.
1969,
Pubmed
Ruben,
Immunological maturation and lymphoreticular cancer transformation in Larval xenopus laevis, the South African clawed toad.
1970,
Pubmed
,
Xenbase
Ruben,
Phenotypic restriction of antigen-binding specificity on immunized amphibian spleen cells.
1977,
Pubmed
,
Xenbase
Takiguchi,
Cellular recognition in vitro by mouse lymphocytes. Effects of neonatal thymectomy and thymus graft restoration on alloantigen and PHA stimulation of whole and gradient-separated subpopulations of spleen cells.
1971,
Pubmed
