XB-ART-30868
Comp Biochem Physiol C Comp Pharmacol
1982 Jan 01;722:257-61. doi: 10.1016/0306-4492(82)90092-2.
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Co-existence of thyrotrophin releasing hormone and 5-hydroxytryptamine in the skin of Xenopus laevis.
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1. The location, release and re-synthesis of thyrotrophin releasing hormone (TRH) and 5-hydroxytryptamine (5-HT) in the skin of Xenopus laevis (the South African clawed toad) have been determined using both morphological and analytical procedures. 2. High levels of TRH and 5-HT are located specifically within the dermal granular glands of X. laevis and discharged from these glands following alpha-adrenergic stimulation. 4. The common occurrence and separate production of high levels of TRH and 5-HT in amphibian skin may provide a model for studying the mechanisms of biosynthesis, interaction and release of these substances in mammalian tissues such as ventral spinal cord, where TRH and 5-HT are found in the same neurones.
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Species referenced: Xenopus laevis
Genes referenced: trh