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XB-ART-30594
Eur J Biochem 1982 Aug 01;1261:23-8.
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Biosynthesis of a gamma 3-melanotropin-like peptide in the pars intermedia of the amphibian pituitary gland.

Martens GJ , Jenks BG , Van Overbeeke AP .


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This study reveals the biosynthesis of a gamma 3-melanotropin-like peptide in the pars intermedia of the pituitary gland of the aquatic toad Xenopus laevis. Pulse-chase experiments in vitro showed that this product is synthesized through processing of a prohormone, pro-opiomelanocortin, and that it is released into the incubation medium. The peptide immunoprecipitated with antiserum to gamma 3-melanotropin, appeared to be a glycopeptide and displayed melanotropic activity. This last observation together with the results of tryptic and chymotryptic peptide mapping of the newly synthesized product indicates that Xenopus gamma 3-melanotropin is structurally different from the proposed mammalian gamma-melanotropins.

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