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XB-ART-30431
Exp Clin Endocrinol 1983 Jan 01;811:3-16. doi: 10.1055/s-0029-1210201.
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Steroid-membrane-adenylate cyclase interactions during Xenopus laevis oocyte meiosis reinitiation: a new mechanism of steroid hormone action.

Baulieu EE .


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Progesterone acts physiologically on Xenopus laevis oocyte meiosis reinitiation in interacting with plasma membrane. Hormonal studies indicate a specific "receptor-like" structure. The involvement of membrane adenylate cyclase activity which is selectively decreased by progesterone is described in intact oocytes as well as in a cell-free membrane containing system. The participation of Ca2+ changes and of phospholipid components of membrane is analyzed. We discuss the possibility that the progesterone-oocyte system is a model for understanding other steroid hormone activities in other target cells.

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