XB-ART-30294
Gen Comp Endocrinol
1983 Mar 01;493:352-7. doi: 10.1016/0016-6480(83)90199-5.
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Regulation of 17 beta-hydroxysteroid oxydoreductase of the Xenopus laevis follicle by gonadotropin and prolactin.
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Ovarian follicles of Xenopus laevis, incubated in vitro actively metabolized radioactive 4-androstene-3, 17-dione to testosterone, indicating the presence of a 17 beta-hydroxysteroid-oxydoreductase (17 beta-HSOR). This enzymatic activity was found to be solely localized in the follicular envelopes. In vitro treatment of follicles with hCG for 2 hr induced a 40% decrease of the 17 beta-HSOR activity. The gonadotropin-induced inhibition was dose-dependent and only observed with gonadotropic LH-like hormones. Concomitant treatment with prolactin completely prevented the hCG effect.
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Species referenced: Xenopus laevis
Genes referenced: prl.1