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XB-ART-29802
Cell Struct Funct 1984 Mar 01;91:97-102. doi: 10.1247/csf.9.97.
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Inhibitor of ribosomal RNA synthesis in Xenopus laevis embryos. VII. Inhibition of 40s pre-rRNA synthesis in Xenopus neurula cells.

Shiokawa K .


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A fraction containing acid-soluble materials (PCA-extract) from Xenopus early blastulae preferentially inhibits the incorporation of [3H]uridine into 18S and 28S rRNA in Xenopus neurula cells. Pulse- laneling experiments revealed that whereas tubercidin, a known inhibitor of rRNA processing, produced a marked accumulation of the label in 40S pre-rRNA, Xenopus inhibitor suppressed labeling of the pre-rRNA. When tubercidin was added to cells whose activity for rRNA synthesis had been lowered by the Xenopus inhibitor, there was still an accumulation of label in the pre-rRNA. These results indicate that Xenopus inhibitor suppresses the synthesis of rRNA at transcription rather than at processing.

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