Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-29680
J Steroid Biochem 1984 Jul 01;211:101-6.
Show Gene links Show Anatomy links

Digitoxigenin, a digitalis steroid, induces meiotic maturation of Xenopus laevis oocytes.

Cartaud A , Marcher K , Ozon R .


???displayArticle.abstract???
Digitoxigenin, a C23 digitalis steroid induces meiotic maturation of Xenopus oocyte. The dose of digitoxigenin which induces half maximal response is 3.3 +/- 2.10(-5)M. In contrast the conjugated digitalis steroid, digitoxin (digitoxigenine + 3 digitoxoses) never triggered maturation at any of the doses tested. These experiments which show that only free digitoxigenin mimics progesterone action, suggest that both digitoxigenin and progesterone possess a common initial site of action which is not localized at the level of the outer leaflet of the oocyte plasma membrane.

???displayArticle.pubmedLink??? 6087028