XB-ART-29671
J Exp Zool
1984 Jul 01;2311:131-6. doi: 10.1002/jez.1402310117.
Show Gene links
Show Anatomy links
ATP-gamma-S (adenosine 5'-0(3-thiotriphosphate)) blocks progesterone-induced maturation of the Xenopus oocyte.
???displayArticle.abstract???
ATP-gamma-S microinjection into Xenopus oocyte prevents progesterone induced maturation. Inhibition is time and dose dependent; 50% inhibition occurs when 50 nl of 0.5 mM ATP-gamma-S solution are microinjected/oocyte 1 hr prior to the hormonal trigger. ATP-gamma-S inhibited oocytes can be induced to mature (100%) following microinjection of extracts containing maturation promoting factor (MPF). Our results suggest that the maturation protein(s) has been stabilized in ovo by ATP-gamma-S microinjection, in its phosphorylated inhibitory form.
???displayArticle.pubmedLink??? 6381639
???displayArticle.link??? J Exp Zool