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XB-ART-29346
Biochem Biophys Res Commun 1985 Jan 16;1261:240-6.
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Afrikander cattle congenital goiter: size heterogeneity in thyroglobulin mRNA.

Ricketts MH , Vandenplas S , van der Walt M , van Jaarsveld PP , Bester AJ , Boyd CD .


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The mRNA coding for thyroglobulin in cattle homozygous for an autosomal recessive defect of thyroglobulin synthesis was investigated using a recombinant plasmid containing bovine mRNA coding sequence. Total RNA preparations from goiter contained one third of the thyroglobulin mRNA sequences found in normal thyroid tissue. This mRNA was not translated into thyroglobulin by Xenopus oocytes. Northern transfer analysis revealed both a normal sized and a smaller thyroglobulin mRNA in the goiter.

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