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XB-ART-29338
FEBS Lett 1985 Jan 28;1802:271-4.
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Regulation of the production of granulocyte-macrophage colony-stimulating factor by macrophage-like tumour cell lines.

Hume DA , Summers KM , Cohen DR , Allan W .


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Macrophage tumour cell lines (PU5-1.8, P388D1) produced detectable granulocyte macrophage colony-stimulating (CSF-2) activity measured using a factor-dependent cell line FDC-P1. The production of CSF-2 was enhanced by endotoxin and inhibited by serum, and correlated inversely with [3H]TdR incorporation. mRNA isolated from PU5-1.8 or P388D1 cells initiated CSF-2 production when injected into Xenopus laevis oocytes. The specific activity in this assay was unaltered in mRNA isolated from endotoxin-treated cells. The results suggest that endotoxin acts at a post-transcriptional level.

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