Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-29178
Nature 1985 Jun 01;3156021:641-7. doi: 10.1038/315641a0.
Show Gene links Show Anatomy links

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs.

March CJ , Mosley B , Larsen A , Cerretti DP , Braedt G , Price V , Gillis S , Henney CS , Kronheim SR , Grabstein K .


???displayArticle.abstract???
Two distinct but distantly related complementary DNAs encoding proteins sharing human interleukin-1 (IL-1) activity (termed IL-1 alpha and IL-1 beta), were isolated from a macrophage cDNA library. The primary translation products of the genes are 271 and 269 amino acids long, although expression in Escherichia coli of the carboxy-terminal 159 and 153 amino acids produces IL-1 biological activity.

???displayArticle.pubmedLink??? 2989698
???displayArticle.link??? Nature


Species referenced: Xenopus