Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Nucleotide sequence of the chicken 5-aminolevulinate synthase gene.
Maguire DJ
,
Day AR
,
Borthwick IA
,
Srivastava G
,
Wigley PL
,
May BK
,
Elliott WH
.
???displayArticle.abstract???
5-Aminolevulinate synthase, the first and rate-controlling enzyme of heme biosynthesis, is regulated in the liver by the end-product heme. To study this negative control mechanism, we have isolated the chicken gene for ALA-synthase and determined the nucleotide sequence. The structural gene is 6.9 kb long and contains 10 exons. The transcriptional start site for ALA-synthase was determined by primer extension analysis. A fragment of 291 bp from the 5' flanking region including 34 bp of the first exon shows promoter activity when introduced upstream of a chicken histone H2B gene and injected into the nuclei of Xenopus laevis oocytes.
Baty,
Mutational dissection of the 21 bp repeat region of the SV40 early promoter reveals that it contains overlapping elements of the early-early and late-early promoters.
1984, Pubmed
Baty,
Mutational dissection of the 21 bp repeat region of the SV40 early promoter reveals that it contains overlapping elements of the early-early and late-early promoters.
1984,
Pubmed
Benoist,
The ovalbumin gene-sequence of putative control regions.
1980,
Pubmed
Benton,
Screening lambdagt recombinant clones by hybridization to single plaques in situ.
1977,
Pubmed
Borthwick,
Purification of 5-aminolaevulinate synthase from liver mitochondria of chick embryo.
1983,
Pubmed
Borthwick,
Molecular cloning of hepatic 5-aminolevulinate synthase.
1984,
Pubmed
Borthwick,
Complete nucleotide sequence of hepatic 5-aminolaevulinate synthase precursor.
1985,
Pubmed
Breathnach,
Organization and expression of eucaryotic split genes coding for proteins.
1981,
Pubmed
Breathnach,
Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries.
1978,
Pubmed
Chen,
The functional human dihydrofolate reductase gene.
1984,
Pubmed
Crouse,
Structure of amplified normal and variant dihydrofolate reductase genes in mouse sarcoma S180 cells.
1982,
Pubmed
Deininger,
Random subcloning of sonicated DNA: application to shotgun DNA sequence analysis.
1983,
Pubmed
Dodgson,
Isolation of the chicken beta-globin gene and a linked embryonic beta-like globin gene from a chicken DNA recombinant library.
1979,
Pubmed
Dynan,
Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins.
,
Pubmed
Everett,
The repeated GC-rich motifs upstream from the TATA box are important elements of the SV40 early promoter.
1983,
Pubmed
Granick,
The induction in vitro of the synthesis of delta-aminolevulinic acid synthetase in chemical porphyria: a response to certain drugs, sex hormones, and foreign chemicals.
1966,
Pubmed
Gunn,
Sequence homology at the 3'-termini of the four RNAs of alfalfa mosaic virus.
1980,
Pubmed
Kao,
Isolation and chromosomal localization of unique DNA sequences from a human genomic library.
1982,
Pubmed
Keller,
Intron splicing: a conserved internal signal in introns of animal pre-mRNAs.
1984,
Pubmed
Kressmann,
Transcription of cloned tRNA gene fragments and subfragments injected into the oocyte nucleus of Xenopus laevis.
1978,
Pubmed
,
Xenbase
Kwoh,
The nucleotide sequence of the chicken thymidine kinase gene and the relationship of its predicted polypeptide to that of the vaccinia virus thymidine kinase.
1984,
Pubmed
Leong,
Analysis of the 5' regulatory region of the gene for delta-aminolevulinic acid synthetase of Rhizobium meliloti.
1985,
Pubmed
Levanon,
Architecture and anatomy of the chromosomal locus in human chromosome 21 encoding the Cu/Zn superoxide dismutase.
1985,
Pubmed
Lewis,
Three expressed sequences within the human beta-tubulin multigene family each define a distinct isotype.
1985,
Pubmed
Marshall,
Interpretation of the properties of chromatin extracts from mammalian nuclei.
1976,
Pubmed
Max,
New twist to DNA methylation.
,
Pubmed
McKnight,
Transcriptional control signals of a eukaryotic protein-coding gene.
1982,
Pubmed
McKnight,
Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: identification of an upstream control region.
1981,
Pubmed
,
Xenbase
Melton,
Structure, expression, and mutation of the hypoxanthine phosphoribosyltransferase gene.
1984,
Pubmed
Messing,
A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments.
1982,
Pubmed
Mount,
A catalogue of splice junction sequences.
1982,
Pubmed
Norrander,
Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis.
1983,
Pubmed
Osborne,
5' end of HMG CoA reductase gene contains sequences responsible for cholesterol-mediated inhibition of transcription.
1985,
Pubmed
Proudfoot,
3' non-coding region sequences in eukaryotic messenger RNA.
1976,
Pubmed
Reynolds,
HMG CoA reductase: a negatively regulated gene with unusual promoter and 5' untranslated regions.
1984,
Pubmed
Sanger,
DNA sequencing with chain-terminating inhibitors.
1977,
Pubmed
Srivastava,
Haem control in experimental porphyria. The effect of haemin on the induction of delta-aminolaevulinate synthase in isolated chick-embryo liver cells.
1980,
Pubmed
Stein,
Pattern of methylation of two genes coding for housekeeping functions.
1983,
Pubmed
Tykocinski,
CG dinucleotide clusters in MHC genes and in 5' demethylated genes.
1984,
Pubmed
Valerio,
Adenosine deaminase: characterization and expression of a gene with a remarkable promoter.
1985,
Pubmed
Vigneron,
Effect of the 21-bp repeat upstream element on in vitro transcription from the early and late SV40 promoters.
1984,
Pubmed
Wallace,
Multiple forms of mammalian deoxyribonucleic acid polymerase. An attempt to relate their interactions with nuclei and free deoxyribonucleic acid in vitro with their possible functions in vivo.
1971,
Pubmed
Wolf,
Clusters of CpG dinucleotides implicated by nuclease hypersensitivity as control elements of housekeeping genes.
,
Pubmed
Yamamoto,
Isolation of recombinant cDNAs encoding chicken erythroid delta-aminolevulinate synthase.
1985,
Pubmed
Yen,
Differential methylation of hypoxanthine phosphoribosyltransferase genes on active and inactive human X chromosomes.
1984,
Pubmed
