XB-ART-28567
FEBS Lett
1986 Sep 01;2051:6-10.
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A single RNA species injected in Xenopus oocyte directs the synthesis of active tyrosine hydroxylase.
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Tyrosine hydroxylase, the rate limiting enzyme in the biosynthesis of catecholamine, is a tetramer composed of four subunits of the same molecular mass. A full length cDNA clone encoding tyrosine hydroxylase has been inserted into the SP6 expression system. Translation of the corresponding RNA in Xenopus oocyte results in enzymatic activity, demonstrating that a single gene contains all the necessary genetic information to code for a functional enzyme. The potential of this system in the analysis of posttranslational tyrosine hydroxylase modifications is discussed.
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Species referenced: Xenopus laevis
Genes referenced: sp6 th